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Joseph E. Alouf "The empirical basis of objective science has thus
nothing 'abso lute' about it. Science does not rest upon solid
bedrock. The bold structure of its theories rises, as it were,
above swamp. It is like a building erected on piles. The piles are
driven down from above into the swamp, but not down to any natural
or 'given' base; and if we stop driving the piles deeper, it is not
because we have reached firm ground. We simply stop when we are
satisfied that the piles are firm enough to carry the structure, at
least for the time being. " -Karl Popper (The Logic of Scientific
Discovery) hen I was invited to write this introductory chapter I
was hon W ored and pleased to have the opportunity to briefly
highlight some important issues relevant to structural aspects of
bacterial protein tox ins. The present book attempts for the first
time to provide into one volume a series of chapters prepared by
invited experts on the struc ture of these fascinating
macromolecules. A particular emphasis is placed on the molecular
features of these highly active biomolecules in rela tion to their
biological properties and mechanisms of action. The researchers in
bacterial protein toxinology of my generation have had the
privilege of witnessing over 40 years the tremen dous development
of this field of biological sciences, particularly in the past
decade.
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