The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system - poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.

The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system - poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.

Measurement of visual acuity has been the cornerstone of visual testing since Snellen began quantitating visual acuity using letter optotypes in the 1860s. Bjerrum in the 1880s brought sophistication and quantitation to the assessment of the visual field with tangent screen examination using differently sized and colored targets. Further advances in visual testing did not occur until the Goldmann perimeter and the Farnsworth Munsell 100 Hue test were introduced in the 1940s, permitting further refinement in the detection and quantitation of acquired visual loss. An explosion of interest in sensory visual function testing followed the demonstration by Quigley and his colleagues in 1982 that despite the loss of more than 40% of the axons in the optic nerve, Snellen acuity and kinetic perimetry remained normal. Much of this interest has focused on a search for more sensitive and disease-specific sensory visual tests. Previously, novel tests used to probe visual function remained in the province of the visual physiologist and psychophysicist. These tests are now being introduced by the ophthalmologist into clinical practice. Concomitantly, the mass production of microcomputers and other technical advances have made tests such as automated perimetry and visual evoked response testing affordable for most offices. The clinician is presently being inundated with a plethora of visual function tests that may require a knowledge of visual psychophysics and statistics to understand and interpret. The purpose of this book is to acquaint the clinician with these new tests so that they may be used to maximum benefit.

Profiles theatre companies in Africa working creatively in the context of financial and political constraints. A close scrutiny of how theatre companies operate is an often neglected aspect of theatre life in Africa, yet, as companies profiled here grapple with the issues of 'creativity and collaboration' much is revealed about the way theatre companies across the continent face the challenges of financial constraints, the political complications of sponsorship and funding, the need for creative or intellectual freedoms, the intricacies of contracts and the crucial decisions about venues and audiences. Volume Editor: JAMES GIBBS, University of the West of England. Series editors: Martin Banham, James Gibbs, Femi Osofisan The contributors include: DEXTER LYNDERSAY, FOLUKE OUGUNLEYE, SIRI LANGE, ALLY MKUMBILA, BRACCO CHITOSA, MANFRED LOIMEIR, LUCY RICHARDSON, CHRISTINE MATZKE, VICTOR S. DUGGA, PATRICK-JUDE OTEH, BASIL JONES, MICHAEL WALLING, BRITISH COUNCIL, JOS REPERTORY THEATRE.

A key volume for Shakespeare, African theatre and postcolonial cultural scholars, promoting debate on the role of Western cultural icons in contemporary postcolonial cultures. This volume takes as its starting point an interrogation of the African contributions to the Globe to Globe festival staged in London in 2012, where 37 Shakespeare productions were offered, each from a different nation. Five African companies were invited to perform and there are articles on four of these productions, examining issues of interculturalism, postcolonialism, language, interpretation and reception. The contributors are both Shakespeare and African theatre scholars, promoting discourse from a range of geographical and cultural perspectives. A critical debate about the process of the Globe to Globe festival is initiated in the form of a discussion article featuringsome of its directors and actors. Two further articles look at Shakespeare productions made purely for Africa, from Mauritius and Cape Verde, and leading Nigerian playwright and cultural commentator Femi Osofisan provides an overview article examining Shakespeare in Africa in the 21st century. The playscript in this volume of African Theatre is Femi Osofisan's Wesoo, Hamlet! or the Resurrection of Hamlet. Volume Editor: JANE PLASTOW Series Editors: Martin Banham, Emeritus Professor of Drama & Theatre Studies, University of Leeds; James Gibbs, Senior Visiting Research Fellow, University of the West of England; Femi Osofisan, Professor of Drama at the University of Ibadan; Jane Plastow, Professor of African Theatre, University of Leeds; Yvette Hutchison, Associate Professor, Department of Theatre & Performance Studies, University of Warwick

Get up to speed on Apache Accumulo, the flexible, high-performance key/value store created by the National Security Agency (NSA) and based on Google's BigTable data storage system. Written by former NSA team members, this comprehensive tutorial and reference covers Accumulo architecture, application development, table design, and cell-level security.

With clear information on system administration, performance tuning, and best practices, this book is ideal for administrators charged with installing and maintaining Accumulo, programmers seeking to write Accumulo applications, and other professionals interested in what Accumulo has to offer. You will find everything you need to use this system fully.Get a high-level introduction on what Accumulo has to offerTake a rapid tour through single- and multiple-node installations, data ingest, and queryLearn how to write Accumulo applications for several use cases, based on examplesDive into Accumulo internals, including information not available in the documentationGet detailed information for installing, administering, tuning, and measuring performanceLearn best practices based on successful implementations in the fieldFind answers to common questions that every new Accumulo user asks

This book has undergone a careful vetting process with the U.S. government to ensure that classified or proprietary information has not been revealed.

We've all asked ourselves the question. It's impossible to look up at the stars and NOT think about it: Are we alone in the universe? Books, movies and television shows proliferate that attempt to answer this question and explore it. In OUT THERE Space.com senior writer Dr. Michael Wall treats that question as merely the beginning, touching off a wild ride of exploration into the final frontier. He considers, for instance, the myriad of questions that would arise once we do discover life beyond Earth (an eventuality which, top NASA officials told Wall, is only drawing closer). What would the first aliens we meet look like? Would they be little green men or mere microbes? Would they be found on a planet in our own solar system or orbiting a star far, far away? Would they intend to harm us, and if so, how might they do it? And might they already have visited? OUT THERE is arranged in a simple question-and-answer format. The answers are delivered in Dr. Wall's informal but informative style, which mixes in a healthy dose of humor and pop culture to make big ideas easier to swallow. Dr. Wall covers questions far beyond alien life, venturing into astronomy, physics, and the practical realities of what long-term life might be like for we mere humans in outer space, such as the idea of lunar colonies, and even economic implications. Readers won't just be hearing from Dr. Wall. As a longtime science journalist--whose work at Space.com is syndicated in outlets from Scientific American to Fox News--he has assembled an impressive array of contacts to provide expert commentary. From a former NASA chief scientist to leading science educators like Neil DeGrasse Tyson and Bill Nye to would-be space traveler Elon Musk, Dr. Wall shares the insights of some of the leading lights in space exploration today, and shows how the next space age might be brighter than ever.

The Sawyer is a novel set in the woods and towns of Northwestern Montana and the men who work in that setting. This story tells a tale of what happens to one of them when things go horribly wrong and how he finds his way back from tragedy to a new kind of normality. It is a story based on the power of friendship and the bond between men and women who have made difficult choices when faced with abnormal difficulties in an environment of some of the most beautiful natural beauty in the country.