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Due to fundamental similarities between the yeast Saccharomyces
cerevisiae and multicellular organisms at the molecular level, and
the powerful range of experimental tools available for this yeast,
S. cerevisiae is proving an ideal model system for studies on
protein synthesis and targeting. The topics covered are: -
Messenger RNA stability and translation.- The translation
apparatus. - Translational control andfidelity. - Protein targeting
to the mitochondrion. - Nuclear transport. - The secretory pathway.
- Protein folding and degradation. - Protein splicing. Modern and
often novel molecular, genetic and biochemical approaches as well
as most recent data are provided. The reader will gain a
comprehensive view of the current status of the field.
Translation, i.e. protein synthesis, studied from a genetic
viewpoint is illustrated in this volume, demonstrating how
researchers are employing both classical genetic and recombinant
DNA techniques in studying the components, mechanisms, regulation
and accuracy of protein synthesis. Both the prokaryotic (especially
"Escherichia coli") and eukaryotic (especially "Saccharomyces
cerevisiae") system are discussed, presenting both new information
and the new genetic approaches available. This book does not
concentrate on one particular aspect of translation, but provides
an ideal overview of the genetic approaches for dissecting the
translation process as well as the current rapid advances made in
the field through the use of "in vitro" genetics.
The last ten years have witnessed a remarkable increase in our
awareness of the importance of events subsequent to transcriptional
initiation in terms of the regulation and control of gene
expression. In particular, the development of recombinant DNA
techniques that began in the 1970s provided powerful new tools with
which to study the molecular basis of control and regulation at all
levels. The resulting investigations revealed a diversity of
post-transcriptional mechanisms in both prokaryotes and eukaryotes.
Scientists working on translation, mRNA stability, transcriptional
(anti)termination or other aspects of gene expression will often
have met at specialist meetings for their own research area.
However, only rarely do workers in different areas of
post-transcriptional control/ regulation have the opportunity to
meet under one roof. We therefore thought it was time to bring
together leading representatives of most of the relevant areas in a
small workshop intended to encourage interaction across the usual
borders of research, both in terms of the processes studied, and
with respect to the evolutionary division prokaryotes/eukaryotes.
Given the breadth of topics covered and the restrictions in size
imposed by the NATO workshop format, it was an extraordinarily
difficult task to choose the participants. However, we regarded
this first attempt as an experiment on a small scale, intended to
explore the possibilities of a meeting of this kind. Judging by the
response of the participants during and after the workshop, the
effort had been worthwhile.
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