This volume complies a set of Data Mining techniques and new applications in real biomedical scenarios. Chapters focus on innovative data mining techniques, biomedical datasets and streams analysis, and real applications. Written in the highly successful Methods in Molecular Biology series format, chapters are thought to show to Medical Doctors and Engineers the new trends and techniques that are being applied to Clinical Medicine with the arrival of new Information and Communication technologies Authoritative and practical, Data Mining in Clinical Medicine seeks to aid scientists with new approaches and trends in the field.

Amie L. Thomasson, the Daniel P. Stone Professor of Intellectual and Moral Philosophy at Dartmouth College, has gained international recognition as a leading figure within various areas of philosophy. She has recently been celebrated as one of the most influential living philosophers for her significant contributions to metaphysics, ontology, phenomenology, and aesthetics. By engaging critically with her approach to metaphysics, modality, conceptual analysis, and the methodological issues concerning ontological questions about ordinary objects, social entities, and fictional characters, as well as including a chapter from Thomasson herself where she makes explicit the internal connections which run through her body of work, this volume delivers the first thorough discussion of Thomasson’s philosophy.

This volume contains the proceedings of the Social Ontology, Normativity, and Philosophy of Law conference, which took place on May 30-31, 2019 at the University of Glasgow. At the invitation of the Social Ontology Research Group, a panel of prominent scholars shed light on normativity from the perspective of social ontology and the philosophy of law.

Raimo Tuomela, late Professor Emeritus at the Centre for Philosophy of Social Sciences (TINT), University of Helsinki, is widely regarded as one of the most important philosophers of our time. He published extensively on various topics within social philosophy; particularly, on social action, cooperation, group belief, group responsibility, group reasoning, social practices, and institutions. To celebrate his legacy, this volume engages with and delves deeply into his philosophy of sociality. By gathering original essays from a world-class line-up of social ontologists, social action theorists, and social philosophers, this collection provides the first comprehensive and critical treatment of Tuomela's outstanding contribution to social ontology and collective intentionality.

Some may consider that the language and concepts of philosophy will eventually be superseded by those of neuroscience. This book questions such a naive assumption and through a variety of perspectives and traditions, the authors show the possible contributions of philosophy to non-reductive forms of neuroscientific research. Drawing from the full range and depth of philosophical thought, from hylomorphism to ethics, by way of dynamical systems, enactivism and value theory, amongst other topics, this edited work promotes a rich form of interdisciplinary exchange. Chapters explore the analytic, phenomenological and pragmatic traditions of philosophy, and most share a common basis in the Aristotelian tradition. Contributions address one or more aspects of subjectivity in relation to science, such as the meaning and scope of naturalism and the place of consciousness in nature, or the relation between intentionality, teleology, and causality. Readers may further explore the nature of life and its relation to mind and then the role of value in mind and nature. This book shows how philosophy might contribute to real explanatory progress in science while remaining faithful to the full complexity of the phenomena of life and mind. It will be of interest to both philosophers and neuroscientists, as well as those engaged in interdisciplinary cooperation between philosophy and science.

Smart polymers react sharply to small changes in physical or chemical conditions and present an intelligent response to chemical stimuli (i.e., chemical species -including biomolecules-, pH, solvents, redox, stimuli that trigger controlled depolymerization) and physical stimuli (i.e., temperature, light, mechanical stress and electrical stimuli). For these reasons, the interest in smart polymers has recently increased exponentially, especially in biological stimuli (i.e., application of polymer-based biosensors, drug delivery, tissue engineering, precision medicine and cell therapy). This book offers a unique opportunity to review the physical-chemical fundamentals of smart polymers, and their behaviour. It also provides an excellent review of the main applications of smart polymers.

Some may consider that the language and concepts of philosophy will eventually be superseded by those of neuroscience. This book questions such a naive assumption and through a variety of perspectives and traditions, the authors show the possible contributions of philosophy to non-reductive forms of neuroscientific research. Drawing from the full range and depth of philosophical thought, from hylomorphism to ethics, by way of dynamical systems, enactivism and value theory, amongst other topics, this edited work promotes a rich form of interdisciplinary exchange. Chapters explore the analytic, phenomenological and pragmatic traditions of philosophy, and most share a common basis in the Aristotelian tradition. Contributions address one or more aspects of subjectivity in relation to science, such as the meaning and scope of naturalism and the place of consciousness in nature, or the relation between intentionality, teleology, and causality. Readers may further explore the nature of life and its relation to mind and then the role of value in mind and nature. This book shows how philosophy might contribute to real explanatory progress in science while remaining faithful to the full complexity of the phenomena of life and mind. It will be of interest to both philosophers and neuroscientists, as well as those engaged in interdisciplinary cooperation between philosophy and science.

This volume complies a set of Data Mining techniques and new applications in real biomedical scenarios. Chapters focus on innovative data mining techniques, biomedical datasets and streams analysis, and real applications. Written in the highly successful Methods in Molecular Biology series format, chapters are thought to show to Medical Doctors and Engineers the new trends and techniques that are being applied to Clinical Medicine with the arrival of new Information and Communication technologies Authoritative and practical, Data Mining in Clinical Medicine seeks to aid scientists with new approaches and trends in the field.

Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immunotherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy.

This open access book offers a comprehensive overview of the history of genomics across three different species and four decades, from the 1980s to the recent past. It takes an inclusive approach in order to capture not only the international initiatives to map and sequence the genomes of various organisms, but also the work of smaller-scale institutions engaged in the mapping and sequencing of yeast, human and pig DNA. In doing so, the authors expand the historiographical lens of genomics from a focus on large-scale projects to other forms of organisation. They show how practices such as genome mapping, sequence assembly and annotation are as essential as DNA sequencing in the history of genomics, and argue that existing depictions of genomics are too closely associated with the Human Genome Project. Exploring the use of genomic tools by biochemists, cell biologists, and medical and agriculturally-oriented geneticists, this book portrays the history of genomics as inseparably entangled with the day-to-day practices and objectives of these communities. The authors also uncover often forgotten actors such as the European Commission, a crucial funder and forger of collaborative networks undertaking genomic projects. In examining historical trajectories across species, communities and projects, the book provides new insights on genomics, its dramatic expansion during the late twentieth-century and its developments in the twenty-first century. Offering the first extensive critical examination of the nature and historicity of reference genomes, this book demonstrates how their affordances and limitations are shaped by the involvement or absence of particular communities in their production.

This open access book offers a comprehensive overview of the history of genomics across three different species and four decades, from the 1980s to the recent past. It takes an inclusive approach in order to capture not only the international initiatives to map and sequence the genomes of various organisms, but also the work of smaller-scale institutions engaged in the mapping and sequencing of yeast, human and pig DNA. In doing so, the authors expand the historiographical lens of genomics from a focus on large-scale projects to other forms of organisation. They show how practices such as genome mapping, sequence assembly and annotation are as essential as DNA sequencing in the history of genomics, and argue that existing depictions of genomics are too closely associated with the Human Genome Project. Exploring the use of genomic tools by biochemists, cell biologists, and medical and agriculturally-oriented geneticists, this book portrays the history of genomics as inseparably entangled with the day-to-day practices and objectives of these communities. The authors also uncover often forgotten actors such as the European Commission, a crucial funder and forger of collaborative networks undertaking genomic projects. In examining historical trajectories across species, communities and projects, the book provides new insights on genomics, its dramatic expansion during the late twentieth-century and its developments in the twenty-first century. Offering the first extensive critical examination of the nature and historicity of reference genomes, this book demonstrates how their affordances and limitations are shaped by the involvement or absence of particular communities in their production.

The nervous system has a remarkable capacity for self-reorganization, and in this first systematic analysis of the interaction between hormones and brain plasticity, Luis Miguel Garcia-Segura proposes that hormones modulate metaplasticity in the brain. He covers a wide variety of hormones, brain regions, and neuroplastic events, and also provides a new theoretical background with which to interpret the interaction of hormones and brain remodeling throughout the entire life of the organism.
Garcia-Segura argues that hormones are indispensable for adequately adapting the endogenous neuroplastic activity of the brain to the incessant modifications in external and internal environments. Their regulation of neuroplastic events in a given moment predetermines new neuroplastic responses that will occur in the future, adapting brain reorganization to changing physiological and behavioral demands throughout the life of the organism. The cross-regulation of brain plasticity and hormones integrates information originated in multiple endocrine glands and body organs with information coming from the external world in conjunction with the previous history of the organism. Multiple hormonal signals act in concert to regulate the generation of morphological and functional changes in neural cells, as well as the replacement of neurons, glial, and endothelial cells in neural networks. Brain remodeling, in turn, is involved in controlling the activity of the endocrine glands and regulating hormonal secretions. This bidirectional adjustment of brain plasticity in response to hormonal inputs, and adjustment of hormonal concentrations in response to neuroplastic events are crucial for maintaining the stability of the inner milieu and for the generation of adequate behavioral responses in anticipation of--and in adaptation to--new social and environmental circumstances and life events, including pathological conditions.

This book constitutes the refereed proceedings of six workshops collocated with the 13th International Conference on Ad-Hoc Networks and Wireless, ADHOC-NOW Workshops 2014, held in Benidorm, Spain, in June 2014. The 25 revised full papers presented were carefully reviewed and selected from 59 submissions. The papers address the following topics: emerging technologies for smart devices; marine sensors and systems; multimedia wireless ad hoc networks; security in ad hoc networks; smart sensor protocols and algorithms; wireless sensor, actuator and robot networks.

Alguien a quien yo queria, mejor dicho a quien yo adoraba, me conto durante mi infancia, siempre que podia, con titanicas dosis de emocion y ternura, una bella historia de una princesa, un campesino y un terrible dragon. La bonita aventura siempre empezaba con una pobre princesa sacrificada, para salvar a su reino, a un terrorifico dragon que la esclavizaba y la retenia prometiendola sufrimientos eternos y un sinfin de penurias. La historia que me contaron entonces me sigue fascinando solo que yo ahora ya puedo contarla con detalles y dar la version real de lo que sucedio.

This is my story of what needs to be done in order to live a happier life, simply by doing exactly what makes you happy. First of all, you need to be cautious because there are many scoundrels out there, only a stone's throw away, that will try their best to stop you dead in your tracks. I know this first hand, because I have often encountered these life sucking predators. They are always on the prowl, masquerading in sheep's clothing ready to do damage to our psyche. Please, don't let them do it to you Remember, you only have one life to live As long as you take the high road in advancing the human condition and not hurting anyone, why not get on board this voyage of self-enhancement. Over the years, I have witnessed the pleasure spread across people's faces when I have asked the question, "What makes you happy?" The overwhelming response has been incredibly positive. In an instant you start to see a soothing change in their facial demeanor. They begin to open up to you as they become immersed in their own story, letting the floodgates loose; as the waters wash away any previously held apprehensions. Try this exercise on your own and you will see what I'm talking about. You will soon inherit a valuable new treasure; inexplicably, via a warp speed change in attitude that is so powerful that they will never forget you or your name. So come aboard this inner vessel and go ahead and ask the Big Question: "What makes YOU happy too"? Because I know "What makes ME happy" and I'm going to share that right now.