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The science of cannabinoids is 50 years old. These past years
provided a remarkable and constant number of breakthroughs, showing
that the signaling mediated by endocannabinoids and lipid mediators
impacts almost every function of the body. Indeed, this represents
a special field of research, which allows tackling the complexity
of biological functions, and provides potential therapeutic
frameworks for a plethora of diseases. The number of exciting
discoveries brought up to the scientific community almost on a
daily basis highlights the importance of an updated volume on this
topic. Particularly, given that potential therapeutic benefits of
cannabis and cannabinoids are currently under heavy analysis in
many Countries worldwide. Hence, the main objective of this book is
to explore not only some of the many functions of endocannabinoids
(and lipid mediators) in physiological control of networks at a
cellular and molecular level, but also to extend this knowledge for
potential use of cannabinoids and/or drugs regulating
endocannabinoid levels in vivo as therapeutic target(s) in
neurological and neuropsychiatric disorders. In this book new
findings and ideas about the endocannabinoid system and its roles
as neuronal circuit modulator related to human brain pathologies
characterized by alterations in neuroplasticity will be
highlighted. Endocannabinoid roles in key systems controlling
appetite, pain, learning and memory, as well as sleep and stress
responses will be presented. In addition, pathological processes
associated with changes in endocannabinoid signaling will be
discussed in the context of anxiety, autism, depression and
addiction. This book will provide an excellent background to
researchers looking for extending their areas of interest, and to
newcomers in the field.
The science of cannabinoids is 50 years old. These past years
provided a remarkable and constant number of breakthroughs, showing
that the signaling mediated by endocannabinoids and lipid mediators
impacts almost every function of the body. Indeed, this represents
a special field of research, which allows tackling the complexity
of biological functions, and provides potential therapeutic
frameworks for a plethora of diseases. The number of exciting
discoveries brought up to the scientific community almost on a
daily basis highlights the importance of an updated volume on this
topic. Particularly, given that potential therapeutic benefits of
cannabis and cannabinoids are currently under heavy analysis in
many Countries worldwide. Hence, the main objective of this book is
to explore not only some of the many functions of endocannabinoids
(and lipid mediators) in physiological control of networks at a
cellular and molecular level, but also to extend this knowledge for
potential use of cannabinoids and/or drugs regulating
endocannabinoid levels in vivo as therapeutic target(s) in
neurological and neuropsychiatric disorders. In this book new
findings and ideas about the endocannabinoid system and its roles
as neuronal circuit modulator related to human brain pathologies
characterized by alterations in neuroplasticity will be
highlighted. Endocannabinoid roles in key systems controlling
appetite, pain, learning and memory, as well as sleep and stress
responses will be presented. In addition, pathological processes
associated with changes in endocannabinoid signaling will be
discussed in the context of anxiety, autism, depression and
addiction. This book will provide an excellent background to
researchers looking for extending their areas of interest, and to
newcomers in the field.
Marijuana is the most commonly used psychotropic drug in the United
States, after alcohol. With the legalization and decriminalization
of cannabis, momentum continues to build and propelled by the
reduction of stigma associated to its consumption, there is growing
concern regarding the long-term impact on brain function and
behavior. Cannabis and the Developing Brain aims to provide
comprehensive research on the effects of cannabis during
neurodevelopment stages (i.e., perinatal and adolescent ages). This
book introduces readers to vivo neural circuits, molecular and
cellular mechanisms affected by cannabis exposure during three
different temporal windows of brain vulnerability. Second, it
offers a unique insight to shared neurobiological features of
cannabinoid exposure during different developmental periods.
Lastly, Cannabis and the Developing Brain determines the adverse
impact of developmental cannabinoid exposure on specific cognition,
emotion and behaviors.
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