This book constitutes the refereed proceedings of the 8th International Conference on Algebraic Informatics, CAI 2019, held in Nis, Serbia, in June/July 2019. The 20 revised papers presented were carefully reviewed and selected from 35 submissions. The papers present research at the intersection of theoretical computer science, algebra, and related areas. They report original unpublished research and cover a broad range of topics from automata theory and logic, cryptography and coding theory, computer algebra, design theory, natural and quantum computation, and related areas.