In the United States, 20.8 million children and adults, 7% of the population, have diabetes. While an estimated 14.6 million have been diagnosed, 6.2 million have yet to be diagnosed. Worldwide diabetes afflicts 150 million people. The World Health Organization estimates that by 2025 that figure will double. Diabetes is responsible for more deaths than AIDS and breast cancer, combined. It is a leading cause of blindness, kidney failure, amputations, heart complications and stroke. Treatment of Type 1 and Type diabetes has changed radically over the past few years. There are new opportunities for treating the key abnormality in diabetes, increased blood glucose, by effective agents such as new insulin preparations and oral agents. Increasing so-called non-glycemic intervention is of prime importance. Blood pressure lowering therapies, anti-cholesterol strategies, and specific treatment related to complications is becoming increasingly important. Pharmacotherapy of Diabetes is a unique, invaluable guide to all aspects of the pharmacological treatment of diabetes, covering basic concepts and an in-depth review of current and future therapies. This work provides an overview for the new changes in therapies that can be implemented in clinical practice and treatment of the diabetic patient.

Looking at anthropologists at work, this book investigates what kind of morality they perform in their occupations and what the impact of this morality is. The book includes ethnographic studies in four professional arenas: health care, business, management and interdisciplinary research. The discussion is positioned at the intersection of ‘applied or public anthropology’ and ‘the anthropology of ethics’ and analyses the ways in which anthropologists can carry out ‘moral work’ both inside and outside of academia.

Looking at anthropologists at work, this book investigates what kind of morality they perform in their occupations and what the impact of this morality is. The book includes ethnographic studies in four professional arenas: health care, business, management and interdisciplinary research. The discussion is positioned at the intersection of 'applied or public anthropology' and 'the anthropology of ethics' and analyses the ways in which anthropologists can carry out 'moral work' both inside and outside of academia.

Drawing on neuroscientific research and metacognitive theory, this groundbreaking volume examines the theoretical implications that are elicited when neural correlates of consciousness (NCC) are identified. The relationship between consciousness and the brain has concerned philosophers for centuries, yet a tacit assumption in much empirically minded consciousness research seems to be that if we can only develop a map of correlations, no further questions remain to be asked. Beyond Neural Correlates of Consciousness starts where others stop, by asking what these correlations may tell us about the nature of consciousness. The book contains chapters considering the upshots of finding the neural correlates of consciousness in light of the most prominent contemporary theories in the field. This illuminates the theoretical consequences of succeeding in the quest for the neural correlates of consciousness from the perspective of global workspace theory, higher-order thought theory, local recurrency theory, and REFCON models, in addition to considering how this quest is shaped by different conscious phenomena, such as dreaming, altered states of consciousness, and different levels of consciousness. This insightful text features sophisticated theories that goes beyond correlational inferences and neural mapping, and will be of interest to students and researchers of consciousness, particularly those interested in interpreting neural correlates.

Drawing on neuroscientific research and metacognitive theory, this groundbreaking volume examines the theoretical implications that are elicited when neural correlates of consciousness (NCC) are identified. The relationship between consciousness and the brain has concerned philosophers for centuries, yet a tacit assumption in much empirically minded consciousness research seems to be that if we can only develop a map of correlations, no further questions remain to be asked. Beyond Neural Correlates of Consciousness starts where others stop, by asking what these correlations may tell us about the nature of consciousness. The book contains chapters considering the upshots of finding the neural correlates of consciousness in light of the most prominent contemporary theories in the field. This illuminates the theoretical consequences of succeeding in the quest for the neural correlates of consciousness from the perspective of global workspace theory, higher-order thought theory, local recurrency theory, and REFCON models, in addition to considering how this quest is shaped by different conscious phenomena, such as dreaming, altered states of consciousness, and different levels of consciousness. This insightful text features sophisticated theories that goes beyond correlational inferences and neural mapping, and will be of interest to students and researchers of consciousness, particularly those interested in interpreting neural correlates.

A narrative ethnography about a Ugandan woman and her relatives, this novelistic, fine-grained volume shows how global questions of responsibility and inequity travel in family networks and confront people with decisions about life and death. It is a story of existence under extremely challenging conditions, about belonging and marginalization, about the opacity and ambiguity of social relations, and about growing up in a country haunted by violence and civil war only to be later lifted by optimism and devastated anew by the AIDS epidemic. The story draws on long-term fieldwork and letters from the woman who takes centre stage in the story, while at once providing unique and privileged insight into the ethical challenges of a research method that demands personal involvement that is ultimately withdrawn for scholarly analysis.

Few complications of systemic diseases are better understood than diabetic nephropathy. In large part, progress in this area is due to Carl Erik Mogensen's steadfast preoccupation over more than three decades with the disorder's epidemiology, pathogenesis, pathophysiology, clinical diagnosis and evolving strategies of management. Though he sparked progress in each of these areas, he generously opens the forum of discussion to many expert contributors to this latest and most comprehensive edition of this exemplary textbook. In eliciting all relevant and up-to-date views, the reader, whether internist, pediatrician or specialist in endocrinology or nephrology, is assured a thorough review of the entire subject and in a format which is exceptionally well-written, well-illustrated and easy to read. Each of the prior editions have been an essential resource for my own work in this field and the 5th edition will no doubt continue to provide the information I and others will require to move forward in the years ahead. If only the other renal diseases were as masterfully synthesized, how much easier our task would be of achieving a comprehensive vision of all else in clinical nephrology. Barry M. Brenner, M.D., Samuel A. Levine Professor of Medicine, Harvard Medical School

The first sporadic observations describing renal abnormalities in diabetes were published late in the 19th century, but systematic studies of the kidney in diabetes started only half a century ago after the paper by Cambier in 1934 and the much more famous study by Kimmelstiel and Wilson in 1936. These authors described two distinct features of renal involvement in diabetes: early hyperfiltration and late nephropathy. Diabetic nephropathy is, despite half a century of studies, still a very pertinent problem, renal disease in diabetes now being a very common cause of end-stage renal failure in Europe and North America and probably throughout the world. It is a very important part of the generalized vascular disease found in long-term diabetes as described by Knud Lundbaek in his mono graph Long-term Diabetes in 1953, published by Munks gaard, Copenhagen. Surprisingly, there has not been a comprehensive volume describing all aspects of renal involvement in diabetes, and the time is now ripe for such a volume summarizing the very considerable research activity within this field during the last decade and especially during the last few years. This book attempts to cover practically all aspects of renal involvement in diabetes. It is written by colleagues who are themselves active in the many fields of medical research covered in this volume: epidemiology, physiology and pathophysiology, laboratory methodology, and renal pathology. New studies deal with the dia gnosis and treatment of both incipient and overt nephropathy by metabolie, antihypertensive, and dietary invention."

This eye-opening book shows how the rights of workers to safe and healthful workplaces are under greater attack today than at any time since the passage of the landmark Occupational Safety and Health Act in 1970. This collection is organized around three thematic issues that pose significant challenges to the Occupational Safety and Health Administration's ability to protect workers' safety and health. First, the economy has shifted from an industrial base to a white collar/service base, which includes more women workers than ever before - yet many of the safety and health problems that affect women are not being adequately addressed. Second, free market ideology and globalization have served to undermine worker safety and health laws. And finally, the effects of 9/11 have exacerbated the trend toward weakening workers' rights and safety standards in the name of national security.

This eye-opening book shows how the rights of workers to safe and healthful workplaces are under greater attack today than at any time since the passage of the landmark Occupational Safety and Health Act in 1970. This collection is organized around three thematic issues that pose significant challenges to the Occupational Safety and Health Administration's ability to protect workers' safety and health. First, the economy has shifted from an industrial base to a white collar/service base, which includes more women workers than ever before - yet many of the safety and health problems that affect women are not being adequately addressed. Second, free market ideology and globalization have served to undermine worker safety and health laws. And finally, the effects of 9/11 have exacerbated the trend toward weakening workers' rights and safety standards in the name of national security.

(Diabetes Forum Series; Vol. 3)

The proceedings cover new perspectives in the field of lexicography, including both theoretical and practical topics, and new aspects of special and bilingual dictionaries. The volume also includes contributions dealing with corpus-based dictionaries, anglicisms, valency, collocations, equivalents, semantics, grammar, etymology, vocabulary, phonetics, euphemisms, pragmatics, and the techniques of computerized dictionary production.

The sum of clinical problems caused by diabetic renal disease has been steadily increasing since the first edition of this book was published in 1988. The years since have seen tremendous progress in research activities. Importantly, this also includes improvement in the treatment programs to prevent end-stage renal failure. It has become clear that the diabetic kidney is extremely pressure-sensitive, responding to effective antihypertensive treatment by retarded progression of disease. Some agents may be more beneficial in this respect than others, although effective blood pressure reduction per se is crucial throughout the stages of diabetic renal disease. However, the prime cause of diabetic renal disease is related to poor metabolic control and it is now documented beyond doubt that good metabolic control is able to postpone or perhaps even prevent the development of renal disease. However, in many individuals we are not able to provide such a quality of control that will prevent complications, and therefore non-glycaemic intervention remains important.Maybe in the future non-glycaemic intervention will become the most important research area in diabetic nephropathy. Much information is now available on the exact mechanisms behind poor metabolic control and development of renal disease. It is likely that a combination of genetic predisposition and metabolic and haemodynamic abnormalities explain the progression to renal disease, seen in about 30% of diabetic individuals. Much of this development probably relates to modifiable genetic factors, such as blood pressure elevation or haemodynamic aberrations. However, mechanisms related to the response to hyperglycaemia are also of clear importance, as is the possibility that these metabolic or haemodynamic pathways may be inhibited. This volume reviews older data as well as the progress seen within the research on diabetic nephropathy over the last five years and describes the state of the art of the development.

We have witnessed a rapid development within the field of the kidney and hypertension in diabetes mellitus. A significant amount of work within the traditional areas has been published, and several new dimensions are now being developed, mostly in the experimental setting. These dimensions are discussed in several chapters of this new edition, The Kidney and Hypertension in Diabetes Mellitus, Fourth Edition. This volume endeavors to cover all aspects of renal involvement in diabetes. It is written by colleagues who are themselves active in the many fields of medical research covered in this volume: epidemiology, physiology and pathophysiology, laboratory methodology and renal pathology.

The first sporadic observations describing renal abnormalities in diabetes were published late in the 19th century, but systematic studies of the kidney in diabetes started only half a century ago after the paper by Cambier in 1934 and the much more famous study by Kimmelstiel and Wilson in 1936. These authors described two distinct features of renal involvement in diabetes: early hyperfiltration and late nephropathy. Diabetic nephropathy is, despite half a century of studies, still a very pertinent problem, renal disease in diabetes now being a very common cause of end-stage renal failure in Europe and North America and probably throughout the world. It is a very important part of the generalized vascular disease found in long-term diabetes as described by Knud Lundbaek in his mono graph Long-term Diabetes in 1953, published by Munks gaard, Copenhagen. Surprisingly, there has not been a comprehensive volume describing all aspects of renal involvement in diabetes, and the time is now ripe for such a volume summarizing the very considerable research activity within this field during the last decade and especially during the last few years. This book attempts to cover practically all aspects of renal involvement in diabetes. It is written by colleagues who are themselves active in the many fields of medical research covered in this volume: epidemiology, physiology and pathophysiology, laboratory methodology, and renal pathology. New studies deal with the dia gnosis and treatment of both incipient and overt nephropathy by metabolie, antihypertensive, and dietary invention."

Positron Annihilation in Chemistry gives a critical review of the chemistry-oriented positron annihilation research. The only three light particles participating in low energy physics and chemistry are the electron, positron, and positronium. Positronium (Ps) is the most important "anomalous" atom.
This volume gives the only available, critical discussion of the chemistry of the two "strange" light particles, the positron and positronium, while the excess electron has been much discussed. Many unusual phenomena in the reaction kinetics of the positron, positronium, and excess electron, and in radiation chemistry and physics, can be investigated in positron annihilation, which also gives important information on defects in solids.

Diabetes is a huge and growing healthcare worry, especially in Western countries. The treatment of both types - 1 and 2 - of this disease has changed radically over the past few years. This work provides an overview of all the changes that will come to be implemented in clinical practice. Summarizing all aspects of treatment, this book delineates the large amount of research work that has been completed over the last few years into the relief of complications in diabetes and vascular medicine in general.

By presenting state-of-the-art aspects of the theory of computation, this book commemorates the 60th birthday of Neil D. Jones, whose scientific career parallels the evolution of computation theory itself.The 20 reviewed research papers presented together with a brief survey of the work of Neil D. Jones were written by scientists who have worked with him, in the roles of student, colleague, and, in one case, mentor. In accordance with the Festschrift's subtitle, the papers are organized in parts on computational complexity, program analysis, and program transformation.

As the complexity of software increases, researchers and practicioners continue to seek better techniques for engineering the construction of evolution of software. Partial evaluation is an attractive technology for modern software construction since it provides automatic tools for software specialization and is based on rigorous semantic foundations. This book is based on a school held at DIKU Copenhagen, Denmark in summer 1998 during which leading researchers summarized the state of the art in partial evaluation. The lectures presented survey the foundations of partial evaluation in a clear and rigorous manner and practically introduce several existing partial evaluators with numerous examples. The second part of the book is devoted to more sophisticated theoretical aspects, advances systems and applications, and highlights open problems and challenges. The book is ideally suited for advanced courses and for self study.

The second edition of this textbook has been fully revised and adds material about loop optimisation, function call optimisation and dataflow analysis. It presents techniques for making realistic compilers for simple programming languages, using techniques that are close to those used in "real" compilers, albeit in places slightly simplified for presentation purposes. All phases required for translating a high-level language to symbolic machine language are covered, including lexing, parsing, type checking, intermediate-code generation, machine-code generation, register allocation and optimisation, interpretation is covered briefly. Aiming to be neutral with respect to implementation languages, algorithms are presented in pseudo-code rather than in any specific programming language, but suggestions are in many cases given for how these can be realised in different language flavours. Introduction to Compiler Design is intended for an introductory course in compiler design, suitable for both undergraduate and graduate courses depending on which chapters are used.

A narrative ethnography about a Ugandan woman and her relatives, this novelistic, fine-grained volume shows how global questions of responsibility and inequity travel in family networks and confront people with decisions about life and death. It is a story of existence under extremely challenging conditions, about belonging and marginalization, about the opacity and ambiguity of social relations, and about growing up in a country haunted by violence and civil war only to be later lifted by optimism and devastated anew by the AIDS epidemic. The story draws on long-term fieldwork and letters from the woman who takes centre stage in the story, while at once providing unique and privileged insight into the ethical challenges of a research method that demands personal involvement that is ultimately withdrawn for scholarly analysis.