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Modified release dosage forms offer definite advantages over
conventional release formulation of the same drug.The three-layered
matrix system overcomes inherent disadvantages of non-linearity
associated with the core, covered by two additional layers, each
with different rates of swelling, gelling and erosion, is what
accounts for the rate of drug release. When the tablet is first
swallowed, the drug concentration is high but the surface area is
small. As time goes by and the core swells, the surface area
expands to compensate for the decrease in drug concentration. Based
on these theoretical considerations the three-layered tablets were
designed and Diclofenac Sodium, a weakly acidic drug and widely
used NSAID, was taken as the model drug to evaluate the comparative
release characteristics from different polymer matrices with
different amount with the variation in the outer layers as well as
in the core.Then the percent release from different batches of
Diclofenac Sodium was plotted against time to get the zero order
plots. In the zero order plots no true straight lines were obtained
but statistically significant differences were found among the
release profile.
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