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Periodontitis is an inflammatory condition of the supporting
tissues of the teeth. Intracellular enzymes are increasingly
released from the damaged cells of periodontal tissues into the
gingival crevicular fluid and saliva. It has been a great challenge
to determine biomarkers for screening and predicting the early
onset of disease (prognostic tests) or evaluating the disease
activity and the efficacy of therapy.Various enzymes evaluated for
the early diagnosis of periodontal disease are aspartate and
alanine aminotransferases ( AST, ALT ), lactate dehydrogenase ( LDH
), creatine kinase ( CK ), alkaline and acid phosphatase ( ALP, ACP
) and gamma glutamiltransferase ( GGT ), myeloperoxidase ( MPO ).
The activities of CK, LDH, AST, ALT, GGT, ALP, ACP, MPO, enzymes
are found to be increased in periodontal diseases. Thus, an attempt
has been made to review the diagnostic value of salivary enzymes in
the diagnosis and progression of periodontal disease.
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