This book constitutes the revised selected papers of the 13th Italian Workshop on Artificial Life and Evolutionary Computation, WIVACE 2018, held in Parma, Italy, in September 2018. The 12 full papers presented were thoroughly reviewed and selected from 30 submissions. They cover the following topics: Boolean networks and complex systems; economic, societal and technological applications; chemical, biological and medical applications. The chapter "Unveiling Latent Relations in the Photonics Techno-Economic Complex System" is open access under a CC BY 4.0 license at link.springer.com.