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This book presents an overview of the most important current
developments in the pre-analytical handling of tissue. It addresses
in particular potential ways to improve the situation whereby
methods employed in the pre-analytical phase – the period from
surgical removal of tissue to the start of pathological processing
– have remained essentially unchanged for decades with only
modest standardization. It is examined how the pre-analytical
period can be optimized, resulting not only in an increase in
diagnostic quality but also in a reduction in processing time and
costs. Among the key topics examined are the so-called cold
ischemia time between tissue removal and fixation, the potential
superiority of vacuum-based preservation over immediate formalin
fixation, two-temperature fixation, molecular analysis methods, and
the pre-analytics of specimens from particular tissues. Readers
will find this book to be an important update that reveals the full
importance of the pre-analytical phase for quality of pathological
work-up.
This book presents an overview of the most important current
developments in the pre-analytical handling of tissue. It addresses
in particular potential ways to improve the situation whereby
methods employed in the pre-analytical phase - the period from
surgical removal of tissue to the start of pathological processing
- have remained essentially unchanged for decades with only modest
standardization. It is examined how the pre-analytical period can
be optimized, resulting not only in an increase in diagnostic
quality but also in a reduction in processing time and costs. Among
the key topics examined are the so-called cold ischemia time
between tissue removal and fixation, the potential superiority of
vacuum-based preservation over immediate formalin fixation,
two-temperature fixation, molecular analysis methods, and the
pre-analytics of specimens from particular tissues. Readers will
find this book to be an important update that reveals the full
importance of the pre-analytical phase for quality of pathological
work-up.
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