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Biochemistry of Collagens, Laminins, and Elastin: Structure,
Function and Biomarkers, Third Edition provides current data on key
structural proteins (collagens, laminins, and elastin), reviews on
how these molecules affect pathologies, and information on how
selected modifications of these proteins can result in altered
signaling properties of the original extracellular matrix (ECM).
Further, it discusses the novel concept that an increasing number
of components of the extracellular matrix harbor cryptic signaling
functions with ties to endocrine function, and how this knowledge
may be used to modulate various pathologies, including fibrotic
disease. This new edition has been expanded and revised to
incorporate recent research advances. Several new chapters explore
a range of chronic diseases in which the ECM and collagens, laminin
and elastin are central players in disease modulation, including
new chapters on lung, skin and intestinal disease, as well as
cancers. The new edition also considers emerging analytical
technologies that can detect biomarkers of ECM degradation, with
discussion of protein quantification and detecting aging of
collagens.
Biochemistry of Collagens, Laminins, and Elastin: Structure,
Function, and Biomarkers provides a comprehensive introduction to
collagen and structural proteins. Type I collagen is one of the
most abundant molecules in the body, playing essential roles in
different tissues, particularly bone and skin. A key aspect of type
I collagen is its post-translational modifications which are
essential for correct synthesis and structural integrity of
collagens, for tissue-specific functionality, as well as for
application as biomarkers of different pathologies. This volume
summarizes current data on key structural proteins (collagens,
laminins and elastin), reviews how these molecules affect
pathologies, and describes selected modifications of proteins that
result in altered signaling properties of the original
extracellular matrix component. Further, it discusses the novel
concept that an increasing number of components of the ECM harbor
cryptic signaling functions that may be viewed as endocrine
functions. Additionally, it highlights how this knowledge can be
exploited to modulate fibrotic disease.
There are 28 different collagens, with 46 unique chains, which
allows for a collagen for each time and place. Some collagens are
specialized for basement membrane, whereas others are the central
structural component of the interstitial matrix. There are eight
collagens among the 20 most abundant proteins in the body, which
makes these molecules essential building blocks of tissues. In
addition, lessons learned from monogenomic mutations in these
proteins result in grave pathologies, exemplifying their importance
in development. These molecules, and their post-translationally
modified products serve as biomarkers of diseases in a range of
pathologies associated with the extracellular matrix. Biochemistry
of Collagens, Laminins, and Elastin: Structure, Function, and
Biomarkers, Second Edition provides researchers and students
current data on key structural proteins (collagens, laminins, and
elastin), reviews on how these molecules affect pathologies, and
information on how selected modifications of proteins can result in
altered signaling properties of the original extracellular matrix
component. Further, it discusses the novel concept that an
increasing number of components of the extracellular matrix harbor
cryptic signaling functions that may be viewed as endocrine
function, and it highlights how this knowledge can be exploited to
modulate fibrotic disease.
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