Stored grain mites are critically dangerous for future concern, in this regard studies were carried out to check the efficacy of aqueous extracts of locally available botanicals (Gardenia jasminoides) and Tobacco (Nicotiana tabacum, ) and selective pesticides (azocyclotin and chlorfenapyr against stored grain mites under CRD. The LC 50 value of gallop showed that gallop killed most mite population and was highly toxic after 14 days of application while azocyclotin (Gallop) was least toxic after 28 days of replication while the EC50 (Effective Concentration) value of chlorfenapyr (Vibrent) showed that chlorfenapyr killed most mite population and was highly toxic after 21 days of application while chlorfenapyr was least toxic after 28 days of replication. In case of gardenia, the LC 50 value showed that gardenia killed most mite population and was highly toxic after 28 days of application while gardenia was least toxic after 7 days of application. LC 50 value of tobacco showed that tobacco killed most mite population and was highly toxic after 7 days of application while tobacco was least toxic after 14 days of application