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Kisspeptin is a key player and regulator of reproduction and exerts
profound effects on male reproductive processes. Degenerative
effects of critical regulators of reproduction, the kisspeptin
peptides, on cellular aspects of sexually immature male gonads are
known but similar information on accessory sex glands remain
elusive. This book, therefore, assess the effects of kisspeptin
treatment by evaluating the cellular architecture at the light and
electron microscopic level and by determining the height of
epithelium in seminal vesicles. In addition DNA damage was analyzed
by DNA ladder assay and DNA fragmentation assay. Kisspeptin-10
exerted a pronounced inhibitory effect on seminal vesicles. It
reduced the height of epithelium and weight of seminal vesicles and
caused considerable DNA damage. Light microscopic examination
evidenced dilatation of the lumen and lack of intricate epithelial
folds. Ultrastructural changes included dilatation of the
endoplasmic reticulum and Golgi cisterns, a reduction of secretory
vesicles and the appearance of autophagic vacuoles. This is the
preliminary study of the effect of kisspeptin on seminal vesicles.
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