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This book provides a compact knowledge about practical applications
of bioinformatic approaches to understand the structure and
function of a protein- Rhodesian which is found in visual pigment
of eye and responsible for controlling night vision. Its structure
has been predicted by comparative homology modelling and model
evaluation through various tools. The electron density maps of
retinal isomers and structure of rhodopsin intermediates were
analyzed by structure superimposition. On the basis of structural
analysis of thirteen mutations for Autosomal Dominant Retinitis
Pigmentosa, one of the missense mutation has been targeted to
propose a drug to cure night blindness. The molecular docking
technique has also been used to predict ligand interactions with
rhodopsin. It is hoped that this will provide new insights into
structural and functional exploration of proteins which will be
helpful in understanding various vital phenomena like protein
activation and inhibition, drug interactions and protein signaling.
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