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This volume discusses how environmental pollutants are involved in
the pathogenesis of neurological disorders, and covers specific
mechanisms and risk factors, as well as the necessary strategies to
reduce the adverse impacts of environmental pollutants on the human
nervous system. With a collection of contributions from experts in
environmental pollution, neurology and pharmaceutical chemistry,
the book provides both an introduction to the pathogenesis of
neurodegeneration, including the types and different classes of
neurological disorders, and studies demonstrating the clear link
between environmental contaminants (e.g. pesticides, smoking,
mycotoxins, persistent organic pollutants (POP's), polychlorinated
biphenyls, phthalates, nanomaterials) and the development of
neurological disorders in vulnerable populations. The book fills in
a gap in research on the topic by also covering state-of-the-art
treatment strategies and mitigation measures for each type of
pollutant. The book will be of interest to environmental
scientists, pharmacologists, toxicologists, biochemists,
biotechnologists, and food and drug regulatory organizations.
This book comprehensively reviews drug stability and chemical
kinetics: how external factors can influence the stability of
drugs, and the reaction rates that trigger these effects.
Explaining the important theoretical concepts of drug stability and
chemical kinetics, and providing numerous examples in the form of
illustrations, tables and calculations, the book helps readers gain
a better understanding of the rates of reactions, order of
reactions, types of degradation and how to prevent it, as well as
types of stability studies. It also offers insights into the
importance of the rate at which the drug is degraded and/or
decomposed under various external and internal conditions,
including temperature, pH, humidity and light. This book is
intended for researchers, PhD students and scientists working in
the field of pharmacy, pharmacology, pharmaceutical chemistry,
medicinal chemistry and biopharmaceutics.
Pharmaceutical Biotechnology in Drug Development summarizes key
concepts and the latest developments of biotechnology applied to
the development of biopharmaceuticals. Chapters present a
comprehensive collection of introductory biotechnology technologies
and their modern concepts and cover pharmacokinetic and
pharmacodynamic behavior of biopharmaceuticals and modification
techniques of amino acids and nucleic acid. Other sections focus on
topics such as gene therapy, immunological preparations and
nanoparticles which are the major contributions of pharmaceutical
biotechnology. Final chapters discuss emerging techniques in the
field of pharmaceutical biotechnology to meet current patient and
health care demand. This book is an essential reference useful for
pharmaceutical scientists, clinicians and academic researchers who
want easy access to up-to-date practices of pharmaceutical
biotechnology. Corporate researchers will also benefit from this
book’s succinct and objective content structure.
Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is
a complete and well-integrated reference on their mechanisms of
action, their role in diseases, agents responsible for their
deactivation, and their malfunction. Chapters explain the
biochemistry of DMEs, including biochemical activation, functions,
computational approaches, different contaminants on the action and
function of DMEs, and describe the importance of DMEs in the drug
development process. Conditions covered include metabolic diseases,
cardiovascular diseases, neurological diseases, physiological
diseases, xenobiotics and inflammatory responses, and their
contribution in the malfunctioning of drug metabolizing enzymes.
This book is the perfect resource for pharmacology and biochemistry
researchers to understand the principles of DMEs. Researchers in
the corporate environment will also benefit from the comprehensive
list of diseases associated with malfunction of DMEs.
This volume discusses how environmental pollutants are involved in
the pathogenesis of neurological disorders, and covers specific
mechanisms and risk factors, as well as the necessary strategies to
reduce the adverse impacts of environmental pollutants on the human
nervous system. With a collection of contributions from experts in
environmental pollution, neurology and pharmaceutical chemistry,
the book provides both an introduction to the pathogenesis of
neurodegeneration, including the types and different classes of
neurological disorders, and studies demonstrating the clear link
between environmental contaminants (e.g. pesticides, smoking,
mycotoxins, persistent organic pollutants (POP's), polychlorinated
biphenyls, phthalates, nanomaterials) and the development of
neurological disorders in vulnerable populations. The book fills in
a gap in research on the topic by also covering state-of-the-art
treatment strategies and mitigation measures for each type of
pollutant. The book will be of interest to environmental
scientists, pharmacologists, toxicologists, biochemists,
biotechnologists, and food and drug regulatory organizations.
Recent advances in the pharmaceutical sciences and biotechnology
have facilitated the production, design, formulation and use of
various types of pharmaceuticals and biopharmaceuticals. This book
provides detailed information on the background, basic principles,
and components of techniques used for the analysis of
pharmaceuticals and biopharmaceuticals. Focusing on those
analytical techniques that are most frequently used for
pharmaceuticals, it classifies them into three major sections and
19 chapters, each of which discusses a respective technique in
detail. Chiefly intended for graduate students in the
pharmaceutical sciences, the book will familiarize them with the
components, working principles and practical applications of these
indispensable analytical techniques.
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