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Since AO and BY has been shown to be indiscriminately added in food
and oil and both have genotoxic and carcinogenic/mutagenic
potential. Hence, following studies are proposed as a part of this
dissertation to fill up the above mentioned lacuna in argemone oil
and butter yellow intoxication. Reproductive toxicity: Consumption
of edible oil adulterated with argemone oil (AO) is also presumed
to be one of the factors for reduction in sperm count and we have
observed that alterations in germ cell apoptosis by a disruption in
contact mediated communication between the Sertoli cells and germ
cells, may subsequently lead to testicular impairment. Hepatic
Toxicity: The study suggests that AO and BY treatment may cause
oxidative stress and diminished phase I & II enzymes leading to
accumulation of parent compound (s) or their metabolites which may
results in the formation of liver cancer. Carcinogenic potential in
gall bladder in vitro and in vivo study suggests that AO and BY are
responsible for producing gall bladder carcinoma in mice along with
stone formation in AO exposure.
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