This book constitutes the refereed joint proceedings of the 1st International Workshop on Ethical & Philosophical Issues in Medical Imaging (EPIMI 2022); the 12th International Workshop on Multimodal Learning and Fusion Across Scales for Clinical Decision Support (ML-CDS 2022) and the 2nd International Workshop on Topological Data Analysis for Biomedical Imaging (TDA4BiomedicalImaging 2022), held in conjunction with the 25th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2022, in Singapore, in September 2022.EPIMI includes five short papers about various humanistic aspects of medical image computing and computer-assisted interventions. The ML-CDS papers discuss machine learning on multimodal data sets for clinical decision support and treatment planning. The TDA papers focus on Topological Data Analysis: a collection of techniques and tools that have matured from an increasing interest in the role topology plays in machine learning and data science.

This book constitutes the refereed joint proceedings of the 4th International Workshop on Interpretability of Machine Intelligence in Medical Image Computing, iMIMIC 2020, and the First International Workshop on Topological Data Analysis and Its Applications for Medical Data, TDA4MedicalData 2021, held on September 27, 2021, in conjunction with the 24th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2021.The 7 full papers presented at iMIMIC 2021 and 5 full papers held at TDA4MedicalData 2021 were carefully reviewed and selected from 12 submissions each. The iMIMIC papers focus on introducing the challenges and opportunities related to the topic of interpretability of machine learning systems in the context of medical imaging and computer assisted intervention. TDA4MedicalData is focusing on using TDA techniques to enhance the performance, generalizability, efficiency, and explainability of the current methods applied to medical data.