This book contains revised and extended versions of the best papers presented at the 16th International Conference on Information and Communication Technologies in Education, Research, and Industrial Applications, ICTERI 2020, held in Kherson, Ukraine, in October 2020. Due to the COVID-19 pandemic the conference was held online. The 8 revised full papers included in this volume were carefully reviewed and selected from 347 initial submissions. The papers are organized in the following topical sections: ICT in education; ICT in research and industry.