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Even if the "weapons of mass destruction" (WMD) and, among them,
stocks of organoph- phorus (OP) agents (also referred to as war
gases and nerve gases) were not found in Iraq following the US-Iraq
war, the relative ease with which these substances can be made from
harmless precursors and the low cost of their manufacture will
continue to fascinate pow- hungry, ruthless dictators, as well as
multinational and international terrorists, particularly as the
close relationship between the OP agents and useful insecticides
makes it easy to disguise the importation and purchase of small
amounts of the precursors. Indeed, the use by Saddam Hussein of a
nerve gas against the Kurds and his possible employment of the OP
agents during his war with Iran, and the Sarin attack in the Tokyo
underground by an extremist religious set magnetized the world with
respect to the OP drugs. As these drugs exert their toxicity via
their cholinergic action on the nervous, particularly central
nervous, system, it is no wonder that the research in the
cholinergic ? eld attracts, and merits, our intense attention.
These considerations underlie the signi? cance of this book, as
Alex Karczmar devotes an entire chapter of Exploring the Vertebrate
Central Cholinergic Nervous System to anticholinest- ases
(antiChEs), and as he is an acknowledged expert in the ? eld of
cholinergic toxicity as well as a consultant to the Surgeon General
of the U. S. Army.
Even if the "weapons of mass destruction" (WMD) and, among them,
stocks of organoph- phorus (OP) agents (also referred to as war
gases and nerve gases) were not found in Iraq following the US-Iraq
war, the relative ease with which these substances can be made from
harmless precursors and the low cost of their manufacture will
continue to fascinate pow- hungry, ruthless dictators, as well as
multinational and international terrorists, particularly as the
close relationship between the OP agents and useful insecticides
makes it easy to disguise the importation and purchase of small
amounts of the precursors. Indeed, the use by Saddam Hussein of a
nerve gas against the Kurds and his possible employment of the OP
agents during his war with Iran, and the Sarin attack in the Tokyo
underground by an extremist religious set magnetized the world with
respect to the OP drugs. As these drugs exert their toxicity via
their cholinergic action on the nervous, particularly central
nervous, system, it is no wonder that the research in the
cholinergic ? eld attracts, and merits, our intense attention.
These considerations underlie the signi? cance of this book, as
Alex Karczmar devotes an entire chapter of Exploring the Vertebrate
Central Cholinergic Nervous System to anticholinest- ases
(antiChEs), and as he is an acknowledged expert in the ? eld of
cholinergic toxicity as well as a consultant to the Surgeon General
of the U. S. Army.
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