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The International Brain Hypothermia Symposium 2004was the second
time I have had the honor of opening such a gathering on brain
hypothermia treatment. It was a great pleasure to greet the
participants in the hope that their valuablecontributions would
make the Tokyo meeting memorable. Brainhypothermia has long been
seen as a promising method that may overcome current limitations on
brain resuscitation in patients with severe brain damage. However,
although excellentresults have been obtained in experimental animal
models, for some reason brain hypothermia has not alwaysbeen
successful clinically, and resolving this problem has been a major
challenge facing physicians specializing in brain therapies. The
ICUmanagement of recent research has uncovered newmechanisms
ofbrain damage not seen in animal models, including brain
thermo-pooling at temperatures above 40 C in severe brain damage,
masking neuronal hypoxia even with normal cerebral blood flow.
Stress-related hyper glycemia with brain hypothermia was expected
to generate useful results in patients with external injuries,
cerebral occlusive stroke, and cardiac arrest. In recent clinical
studies of brain hypothermia treatment, many excellent results
began being reported on the manage ment of severe brain injury,
ischemic stroke, and post-resuscitation after cardiac arrest.
However, in clinical brain hypothermia treatment many questions
remained about appro priate treatment targets, leu management
technique, prevention of complications, control of brain tissue
temperature, management of hypothermia insult, and mechanisms
underly ing the onset of vegetative states."
Analytic Extension is a mysteriously beautiful property of analytic
functions. With this point of view in mind the related survey
papers were gathered from various fields in analysis such as
integral transforms, reproducing kernels, operator inequalities,
Cauchy transform, partial differential equations, inverse problems,
Riemann surfaces, Euler-Maclaurin summation formulas, several
complex variables, scattering theory, sampling theory, and analytic
number theory, to name a few. Audience: Researchers and graduate
students in complex analysis, partial differential equations,
analytic number theory, operator theory and inverse problems.
This book is the proceedings of Falk Symposium 157, entitled
?Chronic Hepatitis: Metabolic, Cholestatic, Viral and Autoimmune?,
held in Freiburg, Germany, on 10--11 October 2006 (one of three
symposia during the XIII Falk Liver Week 2006). It provides
up-to-date information on new developments in the field of chronic
hepatitis and its various entities. In recent decades we have
learned how heterogeneous the clinical entity of chronic hepatitis
has become. The liver, as the central organ of metabolism and
detoxification, is more than ever a target of disease processes
evolving from the spread of obesity in the western world. Apart
from nonalcoholic steatohepatitis (NASH), alcoholic liver disease
is still the most prevalent liver disease in the west...
The International Brain Hypothermia Symposium 2004was the second
time I have had the honor of opening such a gathering on brain
hypothermia treatment. It was a great pleasure to greet the
participants in the hope that their valuablecontributions would
make the Tokyo meeting memorable. Brainhypothermia has long been
seen as a promising method that may overcome current limitations on
brain resuscitation in patients with severe brain damage. However,
although excellentresults have been obtained in experimental animal
models, for some reason brain hypothermia has not alwaysbeen
successful clinically, and resolving this problem has been a major
challenge facing physicians specializing in brain therapies. The
ICUmanagement of recent research has uncovered newmechanisms
ofbrain damage not seen in animal models, including brain
thermo-pooling at temperatures above 40 C in severe brain damage,
masking neuronal hypoxia even with normal cerebral blood flow.
Stress-related hyper glycemia with brain hypothermia was expected
to generate useful results in patients with external injuries,
cerebral occlusive stroke, and cardiac arrest. In recent clinical
studies of brain hypothermia treatment, many excellent results
began being reported on the manage ment of severe brain injury,
ischemic stroke, and post-resuscitation after cardiac arrest.
However, in clinical brain hypothermia treatment many questions
remained about appro priate treatment targets, leu management
technique, prevention of complications, control of brain tissue
temperature, management of hypothermia insult, and mechanisms
underly ing the onset of vegetative states."
Analytic Extension is a mysteriously beautiful property of analytic
functions. With this point of view in mind the related survey
papers were gathered from various fields in analysis such as
integral transforms, reproducing kernels, operator inequalities,
Cauchy transform, partial differential equations, inverse problems,
Riemann surfaces, Euler-Maclaurin summation formulas, several
complex variables, scattering theory, sampling theory, and analytic
number theory, to name a few. Audience: Researchers and graduate
students in complex analysis, partial differential equations,
analytic number theory, operator theory and inverse problems.
Rapid progress in technology and its application to diagnosis and monitoring of brain tissue temperature and metabolism have resulted in advances in therapy for critically brain-injured patients and breakthroughs in understanding the pathophysiology of brain damage. The latest concept of brain hypothermia therapy clarifies targets such as brain thermal pooling, masking brain hypoxia associated with catecholamine surge, the metabolic shift from glucose to lipids, and selective radical damage of dopamine in the central nervous system. This volume explains the mechanism of brain injury and how brain hypothermia treatment differs from other hypothermia therapy in four major sections: Brain Injury Mechanism, Pathophysiology of Hypothermia, Basic Research of Hypothermia Treatment, and Clinical Studies of Brain Hypothermia. The book is a valuable source for practitioners and researchers in neurosurgery and neurology and in critical care and emergency medicine.
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