Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells from patient referral to post-therapy management in a concise and practical format. Providing clinical guidance on the implementation and management of CAR T-cell therapy, this clinical resource keeps you up-to-date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Educational opportunities for pediatric residents and primary care providers that contribute to increased competence in pediatric dermatology are an important component of improving the quality and efficiency of dermatologic care provided to children and adolescents. The 13 articles that comprise this issue have been selected to capture a significant proportion of the most common skin diseases that are seen in children and adolescents. They are intended to provide practical information on diagnosis and initial management that can be performed by the primary care provider and to provide a framework for allowing for more active involvement by the primary care provider with regards to ongoing management of these conditions. From atopic dermatitis to vitiligo, the pediatric primary care provider is guaranteed to see these conditions in their practice. "..covers a wide variety of topics relevant for all pediatricians." Reviewed by BACCH Newsletter, Apr 2015

In this issue of Hematology/Oncology Clinics, guest editors Drs. Sung-Yun Pai and Nirali N. Shah bring their considerable expertise to the topic of Gene-Based Therapies for Pediatric Blood Diseases. Top experts in the field cover key topics such as CAR T-cell therapy: current status; engineered T cells; NK-cell therapy; hemoglobinopathies: beta-thalassemia, sickle cell disease; hemophilia A/B; primary immunodeficiencies; and more. Contains 14 relevant, practice-oriented topics including the evolution of gene therapy; viral vectors in hematopoietic stem cell gene therapy; gene editing in hematopoietic stem cells; nonintegrating vectors and engineered capsids; regulatory aspects of gene therapy; and more. Provides in-depth clinical reviews on gene-based therapies for pediatric blood diseases, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

"Metaphors of Globalization" inquires into the power and politics of metaphors in the making of our globalizing era. The approach is multidisciplinary, with case studies in global finance, global governance, literary theory, political theory, anthropology, and sociology. By revisiting globalization through the analysis of metaphors, this volume sheds new light on usually overlooked dimensions of global politics, improves on many outdated conceptualizations, and undertakes a critical analysis of existing approaches to the study of globalization.

Shah argues that the concept of self-defense in Islamic and International law is compatible. Al-Qaeda's declaration of Jihad does not meet the Islamic legal test. Similarly, the invasion of Iraq does not meet the international legal test. Dr Shah examines those causes attributed to Islam and non-Islamic causes of terrorism and argues that the theory of 'reactive terror' provides the most plausible explanation for so-called Islamic terrorism. The nature of conflicts in Afghanistan and Iraq is changing and Muslim leaders (not including Al-Qaeda or pro Anglo-American governments) may, by consensus, declare Jihad if the occupying forces do not withdraw. Such declaration would be according to Islamic and international law.

The human nervous system-that most complex organization of energy and matter-has yielded a few glimmers of understanding of its operational me chanics during the last two decades. These have mostly been at the biochemical level of structure and function. Throughout history, as one of the mysteries of nature begins to yield some insights into its function, it has been beneficial to look at it from different points of view. We have developed a volume on movement disorders that is primarily directed toward the biochemical understanding of these disorders and their treatment. Each disorder is presented from several points of view. Although this approach leads to some repetition, it is our aim that the final outcome be a more complete understanding. Much has been written about movement: the beauty of the prima ballerina, the strength of the olympic athlete, and the agility of the surgeon. Seldom do we stop to look beneath the surface-the coordination of muscle groups, the finely tuned balance allowing rapid response in either direction, the individual muscle fibers coordinated to maximize strength and agility, and the nerve fibers connecting muscle with nerve centers. Some of these communicate sensory input of position to the centers while others communicate directions of move ment to muscles. We encourage our readers to be constantly alert to the possibility of in creasing their understanding of other nervous system functions, including thought disorder, through an understanding of movement, either in general principle or by specific chemical interaction."

This book includes selected papers from the International Conference on Data Science and Intelligent Applications (ICDSIA 2020), hosted by Gandhinagar Institute of Technology (GIT), Gujarat, India, on January 24-25, 2020. The proceedings present original and high-quality contributions on theory and practice concerning emerging technologies in the areas of data science and intelligent applications. The conference provides a forum for researchers from academia and industry to present and share their ideas, views and results, while also helping them approach the challenges of technological advancements from different viewpoints. The contributions cover a broad range of topics, including: collective intelligence, intelligent systems, IoT, fuzzy systems, Bayesian networks, ant colony optimization, data privacy and security, data mining, data warehousing, big data analytics, cloud computing, natural language processing, swarm intelligence, speech processing, machine learning and deep learning, and intelligent applications and systems. Helping strengthen the links between academia and industry, the book offers a valuable resource for instructors, students, industry practitioners, engineers, managers, researchers, and scientists alike.

The book argues that the concept of self-defense in Islamic and International law is compatible. Al-Qaeda's declaration of Jihad does not meet the Islamic legal test. Similarly, the invasion of Iraq does meet the international legal test.

By revisiting globalization using an analysis of metaphors, such as 'global village' and 'network society', this volume sheds new light on overlooked dimensions of global politics, redresses outdated conceptualizations, and provides a critical analysis of existing approaches to the study of globalization.

Can you imagine your life asthma-free? Yes, yes, and yes. It is possible. Now it's your turn. The AmazingAllergist will show you how. This book is a part of the AmazingAllergist's Awesome Book Series, which empowers allergic children to live great lives. It is a by-product of the author's extensive knowledge, vast experience, and desire to make a difference-one allergic child at a time. This book, through the story of an allergic child, will empower you and your children. What to Expect definitions of "allergy" and "asthma" early allergy recognition information common myths-busted help to overcome fear of allergy tests facts about how you can get better guidance on controlling asthma and allergies at home a fun way for a child to learn a helping hand to live allergy-free instructions on overcoming allergen exposure drug-free treatment options information on the proper use of allergy and asthma medications allergy vaccination relief information checklist for a great and healthy life wonderful free resources and links reliable science-based information Some of the great book reviews for Asthma, and Awesome You: Visit www.AmazingAllergist.com Logo] A portion of the proceeds from this book will help fund the research and education in the areas of allergy, asthma, and immunology. Publisher Info: Bar Code: Mobile Scan Code:

India has given much more to the world, other than zero, numerals, rice, sugar, spices, and mathematics. Book shows how India gave mango, oranges, lemons, tea, milk, pepper, cardamom, cotton, indigo, planned city, comfortable houses, domestication of elephants and chicken, gold, diamond, alphabet, language, literature, epics, fables, algebra, geometry, trigonometry, astronomy, western medicine, surgery, materia medica, first city, river engineeringg, spinning wheel, steel, dams, irrigation, music, shipping, games like chess, and chutes ans ladders, first university, military science, and self-government.

This is a concise summary of information on the incidence, diagnosis, classification and non-surgical treatment of peripheral artery disease (PAD). PAD imposes a significant burden on health care system. Patients suffering from PAD have leg pains, difficulty walking, and lower extremity ulcers. If untreated, this condition can result in limb loss. It is both a life and a limb-threatening condition. It is important to recognise this condition early on, even in the absence of symptoms, in order to provide the best possible therapy in a timely manner. Early and aggressive treatment of PAD is crucial for limb salvage. The surgical therapeutic options for PAD are well-known and described in the literature; however, the information on medical and other non-surgical options for PAD is scattered and not well-summarised. In this book, the authors have attempted to assimilate and summarise in one place all the available information regarding the epidemiology of PAD, clinical features of the disease, clinical and anatomical classification of PAD, medications used to treat PAD, role of fish oil supplementation in PAD and the endovascular therapeutic options for PAD. The authors have summarised the latest available endovascular interventional strategies for the management of aortoiliac, femoropopliteal as well as infrapopliteal PAD. Peripheral vascular intervention is an exciting and ever-changing field, and the authors have attempted to synthesise information from all the major and relevant studies in this field. The authors hope that their book serves as a valuable reference resource for clinicians who are actively involved in the management of patients suffering from PAD, including primary care physicians, cardiologists, vascular surgeons, and cardiovascular fellows in training.