A STEP-BY-STEP APPROACH TO UNDERSTANDING NMR SPECTROSCOPY

Used in concert with complementary analytical techniques such as light spectroscopy and mass spectrometry, Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool for the determination of organic structure. This book fosters a real-world understanding of NMR spectroscopy and how it works without burying the reader in technical details and physical and mathematical formalism. With an accessible, clear style and approach, NMR Spectroscopy Explained:

Introduces readers to modern NMR spectroscopy as it is applied to the analysis of organic compounds and biomolecules

Minimizes complicated theory and focuses on the practical aspects of NMR spectroscopy

Provides comprehensive coverage of how NMR spectroscopy experiments actually work and how to optimize them on the spectrometer

Provides examples of every experiment, with detailed interpretation of data

Presents essential descriptive theory in mainly nonmathematical terms

The guide starts with a basic model and expands it one step at a time, complete with experiments and examples, helping readers who are not experts in physics or physical chemistry to develop an empowering understanding of even the most complex biological NMR spectroscopy techniques. It is an ideal reference for professionals in industry and academia who use NMR spectroscopy technology, NMR facility managers, and upper-level undergraduates and graduate students in organic chemistry, biochemistry, pharmacology, biophysics, and engineering.

Through numerous examples, the principles of the relationship between chemical structure and the NMR spectrum are developed in a logical, step-by-step fashion * Includes examples and exercises based on real NMR data including full 600 MHz one- and two-dimensional datasets of sugars, peptides, steroids and natural products * Includes detailed solutions and explanations in the text for the numerous examples and problems and also provides large, very detailed and annotated sets of NMR data for use in understanding the material * Describes both simple aspects of solution-state NMR of small molecules as well as more complex topics not usually covered in NMR books such as complex splitting patterns, weak long-range couplings, spreadsheet analysis of strong coupling patterns and resonance structure analysis for prediction of chemical shifts * Advanced topics include all of the common two-dimensional experiments (COSY, ROESY, NOESY, TOCSY, HSQC, HMBC) covered strictly from the point of view of data interpretation, along with tips for parameter settings