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In this study, the physiological and molecular effects of two
cholesterol lowering agents, synthetic statin (atorvastatin) and
natural statin (simvastatin) on diabetic and hypercholesterolemic
adult male Wistar albino rats (Rattus norvegicus)at two doses, 10
and 40 mg/kg, for 8 weeks was investigated. Other physiological
parameters were evaluated under this investigation, like: glucose,
urea, uric acid, creatinine, total protein, albumin, globulin, A/G
ratio, total, direct and indirect billirubin) To assess the
beneficial effect of the drugs on liver genomic DNA, the (RE)
analysis with 5 restriction endonucleases manifested variations in
DNA digestion patterns in diabetic and hypercholesterolemic rats
treated with atorvastatin and simavstatin. Such variation reflects
and clarifies a restoration and repairing effect of statin on rat
liver DNA in diabetic and hypercholesterolemic rats.
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