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Recent Advancement in Prodrugs Drugs used as medicines have many
limitations like low chemical stability, aqueous solubility, or
oral absorption/bioavailability, rapid presystemic metabolism,
toxicity, inadequate site specificity, or poor patient
acceptance/compliance (unwanted adverse effects, unacceptable taste
or odor, irritation or pain). Prodrugs design is an approach to
overcome these limitations. Key features Covers recent advancements
in development of prodrugs Presents balanced synthesis and
applications of prodrug chemistry Discusses broad spectrum of
prodrug categories and outlines industrial applications Reviews
prodrugs in cancer nanomedicine, its therapy and treatment
Elucidates mathematical models to study the kinetics of prodrugs
This book covers recent advances in the design of prodrugs. It
contains all the significant recent examples of prodrug chemistry
developments and will aid academics and researchers seeking to
generate new projects in the field.
Novel Drug Delivery Systems for Phytoconstituents discusses general
principles of drug targeting, construction material and
technological concerns of different phytoconstituent in delivery
systems. It focuses on the development of novel herbal formulations
and summarizes their method of preparation, type of active
ingredients, route of administration, biological activity and their
applications. It dicusses therapeutic activities of plant derived
chemicals, their limitations in clinical applications and novel
drug delivery solutions to overcome them to provide better
therapeutic effects with controlled and targeted drug delivery.
Focus on drug delivery of phytomolecules Act as bridge between
natural product scientist and clinical doctors Discusses mechanism
of poor bioavailability of herbal molecules Increases awareness
towards phytochemical efficacy Summarizes efficient novel delivery
systems-based formulations. It extensively covers the applications
of novel drug delivery systems including polymeric nanoparticles,
solid lipid nanoparticles, nanostructured lipid capsules,
liposomes, phytosomes, microsphere, transferosomes, and ethosomes.
Some chapters are especially focused on anticancer phytodrugs,
silymarin, andrographolide, berberine, and curcumin delivery with
special emphasis on their application.
Natural Products in Vector-Borne Disease Management explores the
potential application of natural products in vector control and
disease management. The chapters discuss the global impact of
specific vector-borne diseases, gaps in management, and natural
products in specific stages of development - discovery,
optimization, validation, and preclinical/clinical development.
Toxic effects and mechanisms of action are also discussed. This
book also explores how therapeutic plant derivatives can be used to
combat the vectors of infection and how natural products can be
used to manage and treat vector-borne diseases like malaria,
leishmaniasis, dengue, and trypanosomiasis. With the inclusion of
case studies on field and clinical applications and the
contributions from experts in the field, Natural Products in
Vector-Borne Disease Management is an essential resource to
researchers, academics, and clinicians in parasitology, virology,
microbiology, biotechnology, pharmacology, and pharmacognosy
working in the field of vector-borne diseases.
Advances and Avenues in the Development of Novel Carriers for
Bioactives and Biological Agents provides sound data on the utility
of biological and plant-based drugs and describes challenges faced
in all aspects offering indispensable strategies to use in the
development of bioactive medicines. Bioactive based medications are
commonly used throughout the world and have been recognized by
physicians and patients for their therapeutic efficacy. Bioactive
formulations, including their subordinates and analogs, address 50%
of all medicines in clinical practice. Novel bioactive medicine
transporters can cure many disorders by both spatial and transitory
approaches and have various justifications in medicinal potential.
This book presents information on the utility of natural, plant,
animal and bioengineered bioactive materials. It is a fundamental
source of information and data for pharmacognosists, pharmaceutical
analysts, drug transport scientists and pharmacologists working in
bioactive medications.
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