This volume focuses on the laboratory and clinical experience with targeting viral onco-antigens, while also reviewing the approaches to targeting self-cancer antigens in cancers of non-viral origin, where self-tolerance has been a challenge. It emphasizes the importance of selecting the right vaccine platform to induce a successful immune response against cancer antigens. In addition, the volume discusses the advances made with genetic vaccines, including recent advances with DNA vaccines and the rapid transition of mRNA vaccines from the laboratory to bedside. The new avenues opening up for cancer immunotherapy underline the importance of combinational approaches using cancer vaccines with costimulatory antibodies, which may dramatically improve cancer treatment. This book is intended for all translational researchers and clinicians who aspire to develop novel vaccination approaches for cancer patients with unmet clinical needs.

The war in Ukraine has been fought with, among others, irregular armed groups since 2014--volunteers, paramilitaries, and mercenaries. Based on interviews in the Russian-controlled Donbas and with Ukrainian combatants, the contributions to this volume disclose various micro-dynamics of the mobilization, group formation, and fighting. Who were these fighters and who organized them? Russia has been increasingly employing mercenaries as a way to conduct undeclared, but ruthless wars beyond her borders. Ukraine's formation of irregular armed groups in 2014 was a response to the army's initially glaring inability to counter Russia's military intervention. Most of the irregular battalions acted from the beginning under governmental orders. They have never operated autonomously, but compensated for operational weaknesses of regular armed groups. The initially high power of irregular battalions derived from state support, the capabilities of commanders, social networks, and the faculties of the fighters.