Honorable Mention, Aldo and Jeanne Scaglione Prize for Comparative Literary Studies, Modern Language Association Twenty-first-century philosophy has been drawn into a false opposition between speculation and critique. Nathan Brown shows that the key to overcoming this antinomy is a re-engagement with the relation between rationalism and empiricism. If Kant's transcendental philosophy attempted to displace the opposing priorities of those orientations, any speculative critique of Kant will have to re-open and consider anew the conflict and complementarity of reason and experience. Rationalist Empiricism shows that the capacity of reason and experience to extend and yet delimit each other has always been at the core of philosophy and science. Coordinating their discrepant powers, Brown argues, is what enables speculation to move forward in concert with critique. Sweeping across ancient, modern, and contemporary philosophy, as well as political theory, science, and art, Brown engages with such major thinkers as Plato, Descartes, Hume, Hegel, Marx, Heidegger, Bachelard, Althusser, Badiou, and Meillassoux. He also shows how the concepts he develops illuminate recent projects in the science of measurement and experimental digital photography. With conceptual originality and argumentative precision, Rationalist Empiricism reconfigures the history and the future of philosophy, politics, and aesthetics.

Honorable Mention, Aldo and Jeanne Scaglione Prize for Comparative Literary Studies, Modern Language Association Twenty-first-century philosophy has been drawn into a false opposition between speculation and critique. Nathan Brown shows that the key to overcoming this antinomy is a re-engagement with the relation between rationalism and empiricism. If Kant’s transcendental philosophy attempted to displace the opposing priorities of those orientations, any speculative critique of Kant will have to re-open and consider anew the conflict and complementarity of reason and experience. Rationalist Empiricism shows that the capacity of reason and experience to extend and yet delimit each other has always been at the core of philosophy and science. Coordinating their discrepant powers, Brown argues, is what enables speculation to move forward in concert with critique. Sweeping across ancient, modern, and contemporary philosophy, as well as political theory, science, and art, Brown engages with such major thinkers as Plato, Descartes, Hume, Hegel, Marx, Heidegger, Bachelard, Althusser, Badiou, and Meillassoux. He also shows how the concepts he develops illuminate recent projects in the science of measurement and experimental digital photography. With conceptual originality and argumentative precision, Rationalist Empiricism reconfigures the history and the future of philosophy, politics, and aesthetics.

This collection revisits A Theory of Literary Production (1966) to show how Pierre Macherey's remarkable-and still provocative-early work can contribute to contemporary discussions about the act of reading and the politics of formal analysis. Across a series of historically and philosophically contextualized readings, the volume's contributors interrogate Macherey's work on a range of pressing issues, including the development of a theory of reading and criticism, the relationship between the spoken and the unspoken, the labor of poetic determination and of literature's resistance to ideological context, the literary relevance of a Spinozist materialism, the process of racial subjectification and the ontology of Blackness, and a theorization of the textual surface. Pierre Macherey and the Case of Literary Production also includes three new texts by Macherey, presented here in English for the first time: his postface to the revised French edition of A Theory of Literary Production; "Reading Althusser," in which Macherey analyzes the concept of symptomatic reading; and a comprehensive interview in which Macherey reflects on the historical conditions of his early work, the long arc of his career at the intersection of philosophy and literature, and the ongoing importance of Louis Althusser's thought. Recent translations of Macherey's work into English have introduced new readers to the critic's enduring power and originality. Timely in its questions and teeming with fresh insights, Pierre Macherey and the Case of Literary Production demonstrates the depths to which his work resonates, now more than ever.

Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.