Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Environmental sustainability is one of the biggest issues faced by the mankind. Rapid & rampant industrialization has put great pressure on the natural resources. To make our planet a sustainable ecosystem, habitable for future generations & provide equal opportunity for all the living creatures we not only need to make corrections but also remediate the polluted natural resources. The low-input biotechnological techniques involving microbes and plants can provide the solution for resurrecting the ecosystems. Bioremediation and biodegradation can be used to improve the conditions of polluted soil and water bodies. Green energy involving biofuels have to replace the fossil fuels to combat pollution & global warming. Biological alternatives (bioinoculants) have to replace harmful chemicals for maintaining sustainability of agro-ecosystems. The book will cover the latest developments in environmental biotech so as to use in clearing and maintaining the ecosystems for sustainable future.

Plant microbe interaction is a complex relationship that can have various beneficial impacts on both the communities. An urgent need of today's world is to get high crop yields in an ecofriendly manner. Utilization of beneficial and multifaceted plant growth promoting (PGP) microorganisms can solve the problem of getting enhanced yields without disturbing the ecosystem thus leading to sustainability. For this to achieve understanding of the intricate details of how the beneficial microbes form associations with the host plant and sustain that for millions of years must be known. A holistic approach is required wherein the diversity of microbes associated with plant and the network of mechanisms by which they benefit the host must be studied and utilized. 'Plant Microbe Symbiosis - Fundamentals and Advances' provides a comprehensive understanding of positive interactions that occur between plant and microorganisms and their utilization in the fields. The book reviews the enormous diversity of plant associated microbes, the dialog between plant-microbes-microbes and mechanisms of action of PGP microbes. Utilization of PGPRs as nutrient providers, in combating phytopathogens and ameliorating the stressed and polluted soils is also explained. Importantly, the book also throws light on the unanswered questions and future direction of research in the field. It illustrates how the basic knowledge can be amalgamated with advanced technology to design the future bioformulations.

Plants form mutualistic association with various microorganisms, particularly in the rhizosphere region. The association benefits both the partners in a number of ways. A single plant can support the growth of diverse microbes and in reciprocation these microbes help the plant in several ways. A great deal of knowledge is now available on the mechanisms of action of plant growth promoting microbes in forming association with their partner plant and benefitting it. With ever increasing population and to achieve food security it has become utmost necessary to utilize these friendly microbes to enhance the crop yield and quality in an ecofriendly and sustainable manner. We already know about the huge negative impact of chemicals used in agriculture on the humans and the ecosystems as whole. 'Plant Microbes Symbiosis - Applied Facets' provides a comprehensive knowledge on practical, functional and purposeful utility of plant-microbe interactions. The book reviews the utilization of beneficial microbes for crop yield enhancement and protection against diseases caused by phytopathogens and nutrient deficiencies. The tome also reviews the utility of plant growth promoting microbes in helping the plants to deal with abiotic stresses imposed by climate change and anthropogenic activities. The book showcases how plant-microbe interactions are or can be utilized for reclamation of stressed soils and degradation of pollutants in a most effective and environment friendly manner. It also ascertains the reasons for the below par performance of the microbial based inoculants. The utilization of biotechnological tools for development of next generation bioformulations to combat the new challenges and overcome past hurdles has been discussed. This wonderful association between plants and microbes if used properly will not only enhance the crop yields and reclaim barren lands but also make our planet a better place to live on for all of its habitants.

Computer simulation and mathematical modelling are the most important approaches in the quantitative analysis of the diffusive processes fundamental to many physical, chemical, biological, and geological systems.

This comprehensive text/reference addresses the key issues in the "Modelling and Simulation of Diffusive Processes" from a broad range of different application areas. Applying an holistic approach, the book presents illuminating viewpoints drawn from an international selection of experts across a wide spectrum of disciplines, from computer science, mathematics and engineering, to natural resource management, environmental sciences, applied geo-sciences, agricultural sciences, and theoretical medicine.

Topics and features: presents a detailed introduction to diffusive processes and modelling; discusses diffusion and molecular transport in living cells, and suspended sediment in open channels; examines the mathematical modelling of peristaltic transport of nanofluids, and isotachophoretic separation of ionic samples in microfluidics; reviews thermal characterization of non-homogeneous media, and scale-dependent porous dispersion resulting from velocity fluctuations; describes the modelling of nitrogen fate and transport at the sediment-water interface, and groundwater flow in unconfined aquifers; investigates two-dimensional solute transport from a varying pulse type point source, and futile cycles in metabolic flux modelling; studies contaminant concentration prediction along unsteady groundwater flow, and modelling synovial fluid flow in human joints; explores the modelling of soil organic carbon, and crop growth simulation.

This interdisciplinary volume will be invaluable to researchers, lecturers and graduate students from such diverse fields as computer science, mathematics, hydrology, agriculture and biology.

This book provides the latest research on bioethanol production from first- and second- generation feedstock. Bioethanol has emerged as one of the main alternative biofuels in recent years. The book provides a perspective on the chemistry, sources and production of bioethanol highlighting the recent developments in the field. Through this book readers will learn basic and advanced bioethanol production technologies under one roof, including resource management and environmental and economic impacts. The topics discussed in the book will attract researchers and scholars focusing in this field as well as anyone who is interested in green and sustainable energy resources.

The text focuses on the theory, design, and implementation of the Internet of Things (IoT), in a modern communication system. It will be useful to senior undergraduate, graduate students, and researchers in diverse fields domains including electrical engineering, electronics and communications engineering, computer engineering, and information technology. Features: Presents all the necessary information on the Internet of Things in modern computing Examines antenna integration challenges and constraints in the Internet of Things devices Discusses advanced Internet of Things networks and advanced controllers required for modern architecture Explores security and privacy challenges for the Internet of Things-based health care system Covers implementation of Internet of Things security protocols such as MQTT, Advanced Message Queuing Protocol, XMPP, and DSS The text addresses the issues and challenges in implementing communication and security protocols for IoT in modern computing. It further highlights the applications of IoT in diverse areas including remote health monitoring, remote monitoring of vehicle data and environmental characteristics, industry 4.0, 5G communications, and Next-gen IoT networks. The text presents case studies on IoT in modern digital computing. It will serve as an ideal reference text for senior undergraduate, graduate students, and academic researchers in diverse fields domains including electrical engineering, electronics and communications engineering, computer engineering, and information technology.

This volume explains the recent findings on the mutualistic plant-microbe interactions and how they can be utilized for sustainable agriculture practices including land reclamation. The book covers mainly plant growth promoting microorganisms (PGPMs) including both the symbiotic bacteria and fungi and their role in mobilization of nutrients, providing protection to the crops from phytopathogens and abiotic stresses. PGPMs play important roles in survival and health of the plant. These useful microorganisms provide plants with nutrients, protect them from pathogens and help them combat abiotic stresses. It is important that these mutualistic interactions between plant and soil microbes are well understood so as to develop reliable products in the form of biostimulants and biopesticides, as well as managing biotic and abiotic stresses in crops. Apart from enhancing crop productivity plant-microbe interactions can also perform activities such as reclamation of degraded lands, degradation of pollutants and remediation of saline or marginal lands. This book is of interest to teachers, researchers, plant scientists and microbiologists. Also, the book serves as additional reading material for undergraduate and graduate students of agriculture, microbiology, biotechnology, ecology, soil science and environmental sciences.

This volume provides a comprehensive introduction into methods and procedures on the preparation and characterization of animal tissue-derived extracellular matrix scaffolds primarily from bubaline, caprine, porcine, ovine, rabbit, rat and fish source. Chapters guide readers through decellularization protocol unique to the particular animal tissue and animal studies outcomes. Authoritative and cutting-edge, Tissue Scaffolds aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.

Covers novel semiconductor devices with sub-micron dimensions. Discusses comprehensive device optimization techniques. Examines the conceptualization and modeling of semiconductor devices. Covers circuit and sensor-based application of the novel devices. Discusses novel materials for next-generation devices.

Increasing agro productivity to feed a growing global population under the present climate scenario requires optimizing the use of resources and adopting sustainable agricultural production. This can be achieved by using plant beneficial bacteria, i.e., those bacteria that enhance plant growth under abiotic stress conditions, and more specifically, microorganisms such as plant growth promoting rhizobacteria (PGPR), which are the most promising candidates in this regard. Attaining sustainable agricultural production while preserving environmental quality, agro-ecosystem functions and biodiversity represents a major challenge for current agricultural practices; further, the traditional use of chemical inputs (fertilizers, pesticides, nutrients etc.) poses serious threats to crop productivity, soil fertility and the nutritional value of farm produce. Given these risks, managing pests and diseases, maintaining agro-ecosystem health, and avoiding health issues for humans and animals have now become key priorities. The use of PGPR as biofertilizers, plant growth promoters, biopesticides, and soil and plant health managers has attracted considerable attention among researchers, agriculturists, farmers, policymakers and consumers alike. Using PGPR can help meet the expected demand for global agricultural productivity to feed the world's booming population, which is predicted to reach roughly 9 billion by 2050. However, to do so, PGPR strains must be safe for the environment, offer considerable plant growth promotion and biocontrol potential, be compatible with useful soil rhizobacteria, and be able to withstand various biotic and abiotic stresses. Accordingly, the book also highlights the need for better strains of PGPR to complement increasing agro-productivity.

The role of manufacturing in a country's economy and societal development has long been established through their wealth generating capabilities. To enhance and widen our knowledge of materials and to increase innovation and responsiveness to ever-increasing international needs, more in-depth studies of functionally graded materials/tailor-made materials, recent advancements in manufacturing processes and new design philosophies are needed at present. The objective of this volume is to bring together experts from academic institutions, industries and research organizations and professional engineers for sharing of knowledge, expertise and experience in the emerging trends related to design, advanced materials processing and characterization, and advanced manufacturing processes.

This edited book explores the three interrelated concepts - biomass, bioenergy, and bioeconomy - from the point of view of sustainable advanced conversion processes. It elaborates on processing routes, i.e., how biomass from various sources can be converted into bioenergy like bioethanol, biodiesel, biobutanol, and biogas. Chapters are organized into three sections - "Biomass," "Bioenergy," and "Bioeconomy." The first section very much focuses on biomass-based global research trends and their utilization for future bioenergy options, very particular to microbial activities associated and their practically real-time challenges during lab to land approach. The second section deals with biomass-based applications like biodiesel, bioethanol, biobutanol, biohydrogen, and biomass cookstoves and their future perspectives and challenges. The past, present, and future trends of biomass-based research applications have been assessed and critically evaluated to make the gathered knowledge available in the simplest form for academicians and researchers. The third section focuses on biomass-based policies on implementation and governmental strategies needs a attention to make it smooth for social groups and communities too. The role and impacts of bioeconomy with biomass-based bioenergy options and applications are also targeted here. Sustainable Development Goals are addressed in this section to achieve three objectives (trio), i.e., social, economic, and ecological status, which are the need of the hour for bioeconomic security. Contributions of bioenergy to environmental security have also been addressed in this section, very particular to linkage of sustainable human development. This book is a useful compilation of latest information for researchers and teachers in bioenergy and microbiology. The book also serves as reading material for undergraduate and graduate students of environmental sciences, microbiology, and bioenergy.

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis.This book is the third of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

This volume provides a comprehensive introduction into methods and procedures on the preparation and characterization of animal tissue-derived extracellular matrix scaffolds primarily from bubaline, caprine, porcine, ovine, rabbit, rat and fish source. Chapters guide readers through decellularization protocol unique to the particular animal tissue and animal studies outcomes.  Authoritative and cutting-edge, Tissue Scaffolds aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. 

Bioactive Microbial Metabolites: Scope and Challenges not only focuses on the identification, separation and purification of bioactive metabolites, the book also provides an understanding of the metabolic pathways for bioactive metabolites production that play an important role in modern healthcare as frontline treatments for many diseases. This is a valuable reference for research students, academicians and scientists in environmental microbiology and biotechnology, and for industry personnel related to microbiology/ biotechnology. The science discussed herein plays an important role in expanding the market of antibiotics, food and agriculture but also offers eco-friendly, safer and profitable solutions to respective industries.

Metal Oxide-Based Heterostructures: Fabrication and Applications provides information on synthesis strategies, structural and hierarchical features, morphological characteristics of metal oxide-based heterostructures, and their diverse applications. This book begins with an introduction to the various multidimensional heterostructures, synthesis aspects, and techniques used to control the formation of heterostructures. Then, the impact of synthesis routes on the formation of mixed metal oxide heterostructures and their properties are analyzed. The effect of nonmetal doping, metal doping, and composites of metal oxide heterostructures on the properties of heterostructures is also addressed and that also includes opportunities for optimization of the material's performance for specific applications. Special attention is given to the surface characteristics of the metal oxide heterostructures and their impact on the material's performance, and the applications of metal oxide heterostructures in various fields such as environmental remediation, sensing, organic catalysis, photovoltaics, light emitting materials, and hydrogen production.

This book consists of select proceedings of the International Conference on Emerging Trends in Mechanical and Industrial Engineering (ICETMIE) 2019. It covers current trends in thermal, design, industrial, production and other sub-disciplines of mechanical engineering. This volume focuses on different areas of design engineering including computational mechanics, computational fluid dynamics, finite elements in modelling, simulation, analysis and design, kinematics and dynamics of rigid bodies, micro- and nano-mechanics, solid mechanics and structural mechanics, vibration and acoustics, applied mechanics, and biomechanics. It also covers various topics from thermal engineering including refrigeration plants, heat exchangers, heat pumps and heat pipes, combined heat and power and advanced alternative cycles, polygeneration, combustion processes, heat transfer, solar cells, solar thermal power plants, and the integration of renewable energy with conventional processes. This book will be useful for students, researchers as well as professionals working in the area of mechanical engineering, especially thermal engineering and engineering design and other allied areas.

Single-Phase, Two-Phase and Supercritical Natural Circulation Systems provides readers with a deep understanding of natural circulation systems. This book equips the reader with an understanding on how to detect unstable loops to ensure plant safety and reliability, calculate heat transport capabilities, and design effective natural circulation loops, stability maps and parallel channel systems. Each chapter begins with an introduction to the circulation system before discussing each element in detail and analyzing its effect on the performance of the system. The book also presents thermosyphon heat transport devices in nuclear and other industrial plants, a common information need for students and researchers alike. This book is invaluable for engineers, designers, operators and consultants in nuclear, mechanical, electrical and chemical disciplines.

Discusses the development in design of synthesis process and materials with sustainable approach Covers removal of biotic and abiotic waste from aqueous systems Includes hydrogen energy and biofuels under green energy production Explores removal of environmental (soil and air) contaminants with nanomaterials Reviews advanced materials for environmental remediation in both liquid and gas phase (CO2 removal)

Plants form mutualistic association with various microorganisms, particularly in the rhizosphere region. The association benefits both the partners in a number of ways. A single plant can support the growth of diverse microbes and in reciprocation these microbes help the plant in several ways. A great deal of knowledge is now available on the mechanisms of action of plant growth promoting microbes in forming association with their partner plant and benefitting it. With ever increasing population and to achieve food security it has become utmost necessary to utilize these friendly microbes to enhance the crop yield and quality in an ecofriendly and sustainable manner. We already know about the huge negative impact of chemicals used in agriculture on the humans and the ecosystems as whole. ‘Plant Microbes Symbiosis – Applied Facets’ provides a comprehensive knowledge on practical, functional and purposeful utility of plant-microbe interactions. The book reviews the utilization of beneficial microbes for crop yield enhancement and protection against diseases caused by phytopathogens and nutrient deficiencies. The tome also reviews the utility of plant growth promoting microbes in helping the plants to deal with abiotic stresses imposed by climate change and anthropogenic activities. The book showcases how plant-microbe interactions are or can be utilized for reclamation of stressed soils and degradation of pollutants in a most effective and environment friendly manner. It also ascertains the reasons for the below par performance of the microbial based inoculants. The utilization of biotechnological tools for development of next generation bioformulations to combat the new challenges and overcome past hurdles has been discussed. This wonderful association between plants and microbes if used properly will not only enhance the crop yields and reclaim barren lands but also make our planet a better place to live on for all of its habitants.

This book addresses the key issues in the modeling and simulation of diffusive processes from a wide spectrum of different applications across a broad range of disciplines. Features: discusses diffusion and molecular transport in living cells and suspended sediment in open channels; examines the modeling of peristaltic transport of nanofluids, and isotachophoretic separation of ionic samples in microfluidics; reviews thermal characterization of non-homogeneous media and scale-dependent porous dispersion resulting from velocity fluctuations; describes the modeling of nitrogen fate and transport at the sediment-water interface and groundwater flow in unconfined aquifers; investigates two-dimensional solute transport from a varying pulse type point source and futile cycles in metabolic flux modeling; studies contaminant concentration prediction along unsteady groundwater flow and modeling synovial fluid flow in human joints; explores the modeling of soil organic carbon and crop growth simulation.