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Gene regulatory networks play a vital role in organismal
development and function by controlling gene expression. With the
availability of complete genome sequences, several novel
experimental and computational approaches have recently been
developed which promise to significantly enhance our ability to
comprehensively characterize these regulatory networks by enabling
the identification of respectively their genomic or regulatory
state components, or the interactions between these two in
unprecedented detail. Divided into five convenient sections, Gene
Regulatory Networks: Methods and Protocols details how each of
these approaches contributes to a more thorough understanding of
the composition and function of gene regulatory networks, while
providing a comprehensive protocol on how to implement them in the
laboratory. Written in the highly successful Methods in Molecular
Biology (TM) series format, chapters contain introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and notes
on troubleshooting and avoiding known pitfalls. Authoritative and
accessible, Gene Regulatory Networks: Methods and Protocols aims to
provide novices and experienced researchers alike with a
comprehensive and timely toolkit to study gene regulatory networks
from the point of data generation to processing, visualization, and
modeling.
Gene regulatory networks play a vital role in organismal
development and function by controlling gene expression. With the
availability of complete genome sequences, several novel
experimental and computational approaches have recently been
developed which promise to significantly enhance our ability to
comprehensively characterize these regulatory networks by enabling
the identification of respectively their genomic or regulatory
state components, or the interactions between these two in
unprecedented detail. Divided into five convenient sections, Gene
Regulatory Networks: Methods and Protocols details how each of
these approaches contributes to a more thorough understanding of
the composition and function of gene regulatory networks, while
providing a comprehensive protocol on how to implement them in the
laboratory. Written in the highly successful Methods in Molecular
Biology (TM) series format, chapters contain introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and notes
on troubleshooting and avoiding known pitfalls. Authoritative and
accessible, Gene Regulatory Networks: Methods and Protocols aims to
provide novices and experienced researchers alike with a
comprehensive and timely toolkit to study gene regulatory networks
from the point of data generation to processing, visualization, and
modeling.
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