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These two volumes record the scientific and clinical work presented
at the VIIth International and 3rd European joint symposium on
purine and pyrimidine metabolism in man held at the Bournemouth
International Conference Centre, Bournemouth, UK, from 30th June to
5th July 1991. The series of international meetings at three yearly
intervals have previously been held initially in 1973 in Israel,
then Austria, Spain, the Netherlands, USA and Japan. The European
society for the Study of Purine and Pyrimidine Metabolism in Man
(ESSPPM) which has its own executive and some finance first met in
Switzerland in 1987, then in Germany in 1989. The steady evolution
of the science in this series of meetings is intellectually
satisfying; the subsequent clinical progress is emotionally and
economically reassuring. As befits the position of purines and
pyrimidines at the centre of biochemistry, there has been steady
scientific development into molecular genetics and now onto
developmental controls and biochemical pharmacology. The
complexities of the immune system are being unravelled but an
understanding of the human brain largely eludes us. Laboratory
based scientists now predominate over those who work as clinical
specialists in vii rheumatology, immunology, oncology and
paediatrics. However, there continue to be major clinical
objectives since large sections are concerned with major causes of
death like ATP depletion, cancer and now AIDS; the laboratory work
is providing clinical solutions.
One person in four in the industrialized countries suffers from
hyperuricemia and is therefore at risk of developing gouty
arthritis, nephrolithiasis, or any of the other consequences of
urate deposition. At present, far too little is known about urate
deposition and the mechanisms by which it occurs, as well as about
its clinical consequences, which include formation of toph; over
the helix of the ear or in bones close to joints that have never
exhibited an attack, development of bursitis, chronic
tendovaginitis leading to carpal tunnel syndrome, and gouty
paraplegia. Information on these matters is needed to estimate the
risks of hyperuricemia and to determine when therapeutic
intervention is indicated. The contributions and discussions in
this book, resulting from an international symposium held in
December 1990 in the Medizinische Poliklinik in Munich, provide an
up-to-date source of current knowledge about hyperuricemia in man
and its clinical consequences.
These two volumes record the scientific and clinical work presented
at the VIIth International and 3rd European joint symposium on
purine and pyrimidine metabolism in man held at the Bournemouth
International Conference Centre, Bournemouth, UK, from 30th June to
5th July 1991. The series of international meetings at three yearly
intervals have previously been held initially in 1973 in Israel,
then Austria, Spain, the Netherlands, USA and Japan. The European
society for the Study of Purine and Pyrimidine Metabolism in Man
(ESSPPM) which has its own executive and some finance first met in
Switzerland in 1987, then in Germany in 1989. The steady evolution
of the science in this series of meetings is intellectually
satisfying; the subsequent clinical progress is emotionally and
economically reassuring. As befits the position of purines and
pyrimidines at the centre of biochemistry, there has been steady
scientific development into molecular genetics and now onto
developmental controls and biochemical pharmacology. The
complexities of the immune system are being unravelled but an
understanding of the human brain largely eludes us. Laboratory
based scientists now predominate over those who work as clinical
specialists in vii rheumatology, immunology, oncology and
paediatrics. However, there continue to be major clinical
objectives since large sections are concerned with major causes of
death like ATP depletion, cancer and now AIDS; the laboratory work
is providing clinical solutions.
IV Die Autoren der einzelnen Abschnitte werden in Fussnoten ge
nannt. Die von ihnen verfassten Beitrage reichen jeweils, bis eine
neue Autorennennung erfolgt. Entsprechendes gilt fur die Autoren
angaben im Inhaltsverzeichnis. Im Interesse einer ubersichtlichen
Gliederung war dieses etwas unorthodoxe Vorgehen notig. Einige
ihrer starksten Impulse erhielt die Erforschung der Lipoide durch
die Arbeiten unserer Lehrer SIEGFRIED J. THANN HAUSER und ERNST
KLENK. Es ist uns eine Ehre, ihnen auch an dieser Stelle fur
Anleitung und Vorbild zu danken. Munchen, Marz 1965 NEPOMUK ZOLLNER
und DIETRICH EBERHAGEN Inhaltsverzeichnis I. Chemische Einfuhrung .
. . . . . . . 1 1. Allgemeine Nomenklaturfragen (D. EBERHAGEN) 1 2.
Fettsauren. . . . . . . . . . 2 3. Eigentliche Fette oder Glyceride
7 4. Glycerylather. . . . 9 5. Glycerinphosphatide. . . . 10 6.
Sphingolipoide . . . . . . 16 7. Ganglioside (H. WIEGANDT). 19 8.
Cholesterin und Cholesterinester (D. EBERHAGEN) 29 9. Gallensauren
(B. FROSCH u. H. WAGENER) 31 10. Literaturverzeichnis . . . . . . .
. . . . 33 11. Allgemeine Untersuchungsmethoden . 35 1. Extraktion
der Lipoide aus dem Serum (N. ZOLLNER) 35 2. Gruppentrennungen der
Lipoide (D. EBERHAGEN) . . 39 A. Praparative Verfahren. . . . . . .
. . . . . . 41 a) Fraktionierung durch Acetonfallung der
Phosphatide. 41 b) Fraktionierung durch Dialyse der Neutralfette .
42 c) Fraktionierung auf chromatographischem Wege 44 d)
Chromatographische Auf trennung . . . 46 B. Analytische Verfahren.
. . . . . . . . . . 51 a) Chemische Bestimmungen (D. EBERHAGEN) . .
51 b) Chromatographische Untersuchungen (G. WOLFRAM) 51
DunnBchichtchromatographische Trennung der Gesa- lipoide in die
Lipoidhauptgruppen 56 3. Untersuchung der Phosphatide 57 A.
Praparative Verfahren (H."
Das Buch behandelt alle Aspekte des Purinstoffwechsels sowie den
Purimidinstoffwechsel. Die klinischen Abschnitte werden durch
Kapitel zu denbiochemischen Grundlagen er- g{nzt. Neben der Terapie
von St-rungen des Purinstoffwech- sels wird auch die Bedeutung der
Purinanaloga in der medika- ment-sen Therapie diskutiert, wo sie
z.B. zur Behandlung der HIV-Infektion eingesetzt werden. Das Buch
ist deshalb sowohl f}r denklinisch t{tigen Arzt als auch f}r den
Wis- senschaftler interessant.
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