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New experimental observations often require fresh concepts for
their interpretation, and at times even changes of paradigms. This
is the situation with the recent realization that circulating
endothelial progenitor cells may have an important contribution to
the maintenance and formation of new endothelium in adult
organisms, in a surprisingly wide variety of situations. The
classical paradigm of angiogenesis, centered on the notion of
"sprouting" can hardly accommodate them. It was previously realized
that it needs to be "stretched out" to include alternative
mechanisms of microvascular development, such as intussusception
and capillary fusion. However, a major debate where to reconsider
the sprouting mechanism, and to promote alternative views, did not
take place yet. The number of publications in this field increased
exponentially in the last years. Nevertheless, the concepts and
notions so much needed to describe and to explain the new
observations are still scarce, and heterogeneous. Within the larger
community dedicated to the study of angiogenesis, the researchers
involved in investigation of circulating precursor endothelial
cells biology represent a subgroup with specific preoccupations and
opinions. Many of them did not meet each other so far, and no major
scientific events have been dedicated before exclusively to their
interests. For the above reasons, the idea to organize a symposium
addressing the new developments in angiogenesis research was
received with enthusiasm by all those involved in its preparation.
New experimental observations often require fresh concepts for
their interpretation, and at times even changes of paradigms. This
is the situation with the recent realization that circulating
endothelial progenitor cells may have an important contribution to
the maintenance and formation of new endothelium in adult
organisms, in a surprisingly wide variety of situations. The
classical paradigm of angiogenesis, centered on the notion of
"sprouting" can hardly accommodate them. It was previously realized
that it needs to be "stretched out" to include alternative
mechanisms of microvascular development, such as intussusception
and capillary fusion. However, a major debate where to reconsider
the sprouting mechanism, and to promote alternative views, did not
take place yet. The number of publications in this field increased
exponentially in the last years. Nevertheless, the concepts and
notions so much needed to describe and to explain the new
observations are still scarce, and heterogeneous. Within the larger
community dedicated to the study of angiogenesis, the researchers
involved in investigation of circulating precursor endothelial
cells biology represent a subgroup with specific preoccupations and
opinions. Many of them did not meet each other so far, and no major
scientific events have been dedicated before exclusively to their
interests. For the above reasons, the idea to organize a symposium
addressing the new developments in angiogenesis research was
received with enthusiasm by all those involved in its preparation.
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