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Medicinal chemistry is both science and art. The science of
medicinal chemistry offers mankind one of its best hopes for
improving the quality of life. The art of medicinal chemistry
continues to challenge its practitioners with the need for both
intuition and experience to discover new drugs. Hence sharing the
experience of drug research is uniquely beneficial to the field of
medicinal chemistry. Drug research requires interdisciplinary
team-work at the interface between chemistry, biology and medicine.
Therefore, the topic-related series Topics in Medicinal Chemistry
covers all relevant aspects of drug research, e.g.
pathobiochemistry of diseases, identification and validation of
(emerging) drug targets, structural biology, drugability of
targets, drug design approaches, chemogenomics, synthetic chemistry
including combinatorial methods, bioorganic chemistry, natural
compounds, high-throughput screening, pharmacological in vitro and
in vivo investigations, drug-receptor interactions on the molecular
level, structure-activity relationships, drug absorption,
distribution, metabolism, elimination, toxicology and
pharmacogenomics. In general, special volumes are edited by well
known guest editors.
Medicinal chemistry is both science and art. The science of
medicinal chemistry offers mankind one of its best hopes for
improving the quality of life. The art of medicinal chemistry
continues to challenge its practitioners with the need for both
intuition and experience to discover new drugs. Hence sharing the
experience of drug research is uniquely beneficial to the field of
medicinal chemistry. Drug research requires interdisciplinary
team-work at the interface between chemistry, biology and medicine.
Therefore, the topic-related series Topics in Medicinal Chemistry
covers all relevant aspects of drug research, e.g.
pathobiochemistry of diseases, identification and validation of
(emerging) drug targets, structural biology, drugability of
targets, drug design approaches, chemogenomics, synthetic chemistry
including combinatorial methods, bioorganic chemistry, natural
compounds, high-throughput screening, pharmacological in vitro and
in vivo investigations, drug-receptor interactions on the molecular
level, structure-activity relationships, drug absorption,
distribution, metabolism, elimination, toxicology and
pharmacogenomics. In general, special volumes are edited by well
known guest editors.
Applications of Heterocycles in the Design of Drugs and
Agricultural Products, Volume 134 in the Advances in Heterocyclic
Chemistry series represents the most definitive series in the field
- one of great importance to organic chemists, polymer chemists,
and many biological scientists. Chapters in this updated volume
cover Hydroxy azoles as carboxylic acid bioisosteres, Cyclic
sulfoxides and sulfones in drug design, Thiazoles and topological
control in drug design, Applications of fused pyrrolidine [3.3.0]
heterocycles in drug design, 1,4 Disubstituted and 1,4,5
trisubstituted-1,2,3-triazoles in drug discovery and development:
from the flask to the clinic, and Conformationally restricted
[3.2.2]- and [3.2.1]-3-azabicyclic diamines. Because biology and
organic chemistry increasingly intersect, the associated
nomenclature is being used more frequently in explanations. Written
by established authorities in the field from around the world, this
comprehensive review combines descriptive synthetic chemistry and
mechanistic insight to yield an understanding of how chemistry
drives the preparation and useful properties of heterocyclic
compounds.
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