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Because of the recent advances in embryo modeling techniques, and
at the request of the Office of Science Policy in the Office of the
Director at the National Institutes of Health, the National
Academies of Sciences, Engineering, hosted a 1-day public workshop
that would explore the state of the science of mammalian embryo
model systems. The workshop, which took place on January 17, 2020,
featured a combination of presentations, panels, and general
discussions, during which panelists and participants offered a
broad range of perspectives. Participants considered whether embryo
model systems - especially those that use nonhuman primate cells -
can be used to predict the function of systems made with human
cells. Presentations provided an overview of the current state of
the science of in vitro development of human trophoblast. This
publication summarizes the presentation and discussion of the
workshop. Table of Contents Front Matter 1 Introduction and
Overview 2 Mammalian Embryo Research and Pluripotent Stem Cells 3
Examining the Development of Extraembryonic Lineages 4 Stem
CellBased Models of Human Embryos 5 Comparative Embryonic
Development Across Species 6 Exploring Opportunities and Challenges
with Mammalian Embryo Model Systems References Appendix A: Workshop
Agenda Appendix B: Speaker Biographical Sketches Appendix C:
Statement of Task Appendix D: Registered Attendees
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