Introduction; M. Ginsberg, et al. Metabolic Correlates of Focal Ischemia; W.D. Lust, et al. Role of Pyruvate Dehydrogenase in Ischemic Injury; F.A. Welsh. Disturbances of Protein and Polyamine Metabolism After Reversible Cerebral Ischemia; K.A. Hossman, W. Paschen. Oxygen Dependence of Neuronal Metabolism; D.A. Wilson. Lipid Dysmetabolism in Brain Ischemia; K. Kogure. Involvement of Calcium, Lipolytic Enzymes, and Free Fatty Acids in Ischemic Brain Trauma; A.A. Farooqui, et al. Arachidonic Acid Lipoxygenase Products Participate in the Pathogenesis of Delayed Cerebral Ischemia; T. Watanabe, et al. Biochemical Changes and Secondary Tissue Injury After Brain and Spinal Cord Ischemia; A.I. Faden, et al. Free Fatty Acid Liberation in the Pathogenesis and Therapy of Ischemic Brain Damage; E.M. Nemoto, et al. Cerebral Ischemia and Polyphosphoinositide Metabolism; G.Y. Sun. 6 additional articles. Index.

Phospholipases A2: Brain Phospholipases and their Role in Signal Transduction; A.A. Farooqui, et al. Cell Signaling and Essential Fatty Acids: Reciprocal Regulation of Fatty Acid Release in the Brain by GABA and Glutamate; D.L. Birkle Metabolites of Essential Fatty Acids and Other MembraneDerived Second Messengers in Cell Signaling: A Role for the Arachidonic Acid Cascade in Fast Synaptic Modulation A. Volterra, et al. Dietary Supply of Essential Fatty Acids, Synaptogenesis, and Photoreceptor Biogenesis: Network of Signal Transduction Pathways Involving Lipids; R. Bell et al. Essential Fatty Acids, Excitable Membrane Phospholipids, and Pathophysiology: Conservation of Docosahexaenoic Acid in the Retina; R.E. Anderson, et al. Essential Fatty Acids and Excitable Membrane Phospholipids: Disposition Kinetics of Phospholipid Liposomes; P. Palatini 32 additional articles. Index.

volume of conference proceedings reviews the general pathophysiological significance of the isoforms of cyclooxygenase, and the likely value of selective COX-2 inhibitors in the treatment of rheumatoid conditions. Also covered is the possible use of antibodies against cytokines and cell adhesion receptors in the treatment of inflammatory conditions.

In this timely volume, eminent researchers provide detailed coverage of the relevant function of neurochemical correlates to cerebral ischemia as well as their pathophysiological significance.