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This book covers the current understanding of the role of
activation-induced cytidine deaminase (AID) in the generation of
antibody response to antigenic challenge. Since the discovery of
AID, and the genetic demonstration of its role in somatic
hypermutation and class-switch recombination of antibody genes,
much has been learned about the biochemistry of this enzyme.
However, some key questions remain hotly contested, such as: how
does this enzyme get to the antibody locus leaving the rest of the
genome intact, and why are DNA repair pathways which normally
repair deamination events co-opted into actually fixing mutations
into the genome? These questions, among others, will be addressed
in this monograph from various perspectives. Being leading experts
in their respective fields, the contributors of this highly valued
title summarize current research in the field of AID and put forth
hypotheses in order to provide a platform for future experiments.
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