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Longitudinal studies often incur several problems that challenge
standard statistical methods for data analysis. These problems
include non-ignorable missing data in longitudinal measurements of
one or more response variables, informative observation times of
longitudinal data, and survival analysis with intermittently
measured time-dependent covariates that are subject to measurement
error and/or substantial biological variation. Joint modeling of
longitudinal and time-to-event data has emerged as a novel approach
to handle these issues. Joint Modeling of Longitudinal and
Time-to-Event Data provides a systematic introduction and review of
state-of-the-art statistical methodology in this active research
field. The methods are illustrated by real data examples from a
wide range of clinical research topics. A collection of data sets
and software for practical implementation of the joint modeling
methodologies are available through the book website. This book
serves as a reference book for scientific investigators who need to
analyze longitudinal and/or survival data, as well as researchers
developing methodology in this field. It may also be used as a
textbook for a graduate level course in biostatistics or
statistics.
Longitudinal studies often incur several problems that challenge
standard statistical methods for data analysis. These problems
include non-ignorable missing data in longitudinal measurements of
one or more response variables, informative observation times of
longitudinal data, and survival analysis with intermittently
measured time-dependent covariates that are subject to measurement
error and/or substantial biological variation. Joint modeling of
longitudinal and time-to-event data has emerged as a novel approach
to handle these issues. Joint Modeling of Longitudinal and
Time-to-Event Data provides a systematic introduction and review of
state-of-the-art statistical methodology in this active research
field. The methods are illustrated by real data examples from a
wide range of clinical research topics. A collection of data sets
and software for practical implementation of the joint modeling
methodologies are available through the book website. This book
serves as a reference book for scientific investigators who need to
analyze longitudinal and/or survival data, as well as researchers
developing methodology in this field. It may also be used as a
textbook for a graduate level course in biostatistics or
statistics.
Privileged Scaffolds in Drug Discovery is the most complete
and up-to-date work in the area. Covering a wide
range of privileged structures, it is a perfect reference for
scientists involved in targeted drug development. The editors
recruited epserts from several prestigious Chinese
institutions to cover the areas of antiviral drugs, chalcone,
pyrimidine, (benz)imidazoles, natural product-derived privileged
scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor
molecules, antineurodegenerative drugs, triazoles, oxazolidinone,
indole and indoline scaffolds, tigliane diterpenoids, peptide and
peptide-based drugs, quassinoids, and others including
pseudonatural products, macrocycles, stable peptides and
peptidomimetics. The book also explores scaffolds in drug
molecules approved in recent years. Privileged Scaffolds in Drug
Discovery is a complete reference for researchers in drug
discovery and organic synthesis, in academic and corporate
settings, who are investigating privileged structures upon
which to base new drugs. Researchers in medicinal chemistry
and chemical biology will also find the contents of this book
valuable.
A novel strain of influenza A (H1N1) virus emerged and an outbreak
of influenza A (H1N1) occurred worldwide in 2009 and 2010, posing a
severe threat to the health of human beings. The two Editors work
together in Beijing You An Hospital, to combat this type of
influenza. This book, Radiology of Influenza A (H1N1), is intended
to provide first-hand clinical data and its scientific analysis,
thus supporting sound clinical practice for influenza A (H1N1)
prevention and treatment as well as related scientific research.
The authors have collected over 100 critical influenza A (H1N1)
virus-infected cases. For cases of influenza A (H1N1) that resulted
in death, autopsies were performed for 8 cases after receiving
their families' informed consent. Over 200 reports on pathological
and histological analysis as well as immunohistochemical and
electroscopic analysis were brought together. This book was then
compiled by comparing the published data with the present
first-hand data. This book includes a wealth of content, including
DR, CT and MRI images, pathological and histological figures, and
immunohistochemical and electroscopic figures. Related research,
clinical and educational needs can be readily satisfied by its
detailed data, texts and figures, as well as typical case reports.
Li Hongjun, is professor and director of the diagnostic radiology
department in Beijing You An Hospital, affiliated with Capital
Medical University, Beijing, China. Li Ning, is professor and
president of Beijing You An Hospital, affiliated with Capital
Medical University, Beijing, China.
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Mobile Computing, Applications, and Services - 12th EAI International Conference, MobiCASE 2021, Virtual Event, November 13-14, 2021, Proceedings (Paperback, 1st ed. 2022)
Shuiguang Deng, Albert Zomaya, Ning Li
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R1,897
Discovery Miles 18 970
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Ships in 10 - 15 working days
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This book constitutes the thoroughly refereed post-conference
proceedings of the 12th International Conference on Mobile
Computing, Applications, and Services, MobiCASE 2021, held in
November 2021. Due to COVID-19 pandemic the conference was held
virtually. The 9 full papers were carefully reviewed and selected
from 21 submissions. The papers are organized in two topical
tracks: mobile application and deep learning, and mobile
application with data analysis.
Over-pumping of aquifers is a worldwide problem, mainly caused by
agricultural water use. Among its consequences are the falling dry
of streams and wetlands, soil subsidence, die-off of phreatophytic
vegetation, saline water intrusion, increased pumping cost and loss
of storage needed for drought relief. Stopping or reversing the
trend requires management interventions. The North China Plain
serves as an example. A management system is set up for a typical
county. It contains three components: monitoring, decision support
based on modelling, and implementation in the field. Besides all
monitoring data, the decision support module contains an irrigation
calculator, a box model, and a distributed groundwater model to
project the outcomes of different water allocation scenarios. In
view of grain security, a solution combines an adaptation of the
cropping system with imports of surface water from the South. The
Open Access book does not only describe the problem and the path to
its solution. It also gives access to nine manuals concerning
methods used. They include computer programs and the game Save the
Water. The Chinese experience should be of considerable interest to
other regions in the world which suffer from over-pumping of
aquifers.
Over-pumping of aquifers is a worldwide problem, mainly caused by
agricultural water use. Among its consequences are the falling dry
of streams and wetlands, soil subsidence, die-off of phreatophytic
vegetation, saline water intrusion, increased pumping cost and loss
of storage needed for drought relief. Stopping or reversing the
trend requires management interventions. The North China Plain
serves as an example. A management system is set up for a typical
county. It contains three components: monitoring, decision support
based on modelling, and implementation in the field. Besides all
monitoring data, the decision support module contains an irrigation
calculator, a box model, and a distributed groundwater model to
project the outcomes of different water allocation scenarios. In
view of grain security, a solution combines an adaptation of the
cropping system with imports of surface water from the South. The
Open Access book does not only describe the problem and the path to
its solution. It also gives access to nine manuals concerning
methods used. They include computer programs and the game Save the
Water. The Chinese experience should be of considerable interest to
other regions in the world which suffer from over-pumping of
aquifers.
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