In present research work, dispersible tablets of cefpodoxime proxetil were formulated using dry granulation technique. Cefpodoxime proxetil is an advanced-generation, broad-spectrum cephalosporin antibiotic. Cefpodoxime proxetil has slightly bitter taste and has poor water solubility. So in case of acute bacterial exacerbation of chronic bronchitis (AECB) groupA beta-hemolytic streptococcal pharyngotonsillitis, and uncomplicated skin/skin structure infections it require immediate release of drug from the dosage form, which make Cefpodoxime Proxetil suitable candidate for dispersible tablets.

For the drug delivery oral drug delivery is most convenient. For getting the maximum effect on the stomach or for particularly stomach targeted drug are must present in stomach for long time. So for these various approaches are available in this research work for gastroretentive drug delivery system. Methods, Advantages, Limitations and Applications for these drug delivery system is describes in this work. I done my best to cover all information. Thank you.