This volume in "The Year in Immunology" series focuses on reviews covering novel approaches to understanding immunoregulatory mechanisms and immune signaling. A wide range of topics is covered within this volume, including lineage determination of T cells, roles of various receptors in B cell activation, activation of basophils, micro-RNAs (miRNAs) in inflammation and immunity, and autoimmune disorders.

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This volume in The Year in Immunology series focuses on reviews covering novel approaches to our understanding of immunoregulatory mechanisms. A wide-range of topics is covered within this volume, including: Lineage determination of T cellsRoles of various receptors in B-cell activationActivation of plasmactyoid dendritic cellsMicro-RNAs (miRNAs) in inflammation and immunityAutoimmune disorders

NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Experts in microbiology and autoimmunity examine the association between microorganisms and the development of specific categories of autoimmune diseases. The opening chapters explore the bacterial induction of diseases considered autoimmune in nature. Subsequent chapters describe the role of viruses in the induction of these diseases and of diseases with an autoimmune component. Specific topics include: the role of streptococcal infection in rheumatic fever and the role of Klebsiella in the development of ankylosing spondylitis.

Volume Immunodeficiency Diseases in Springer's gold-standard reference work on medical immunology focuses on infectious diseases. In tandem with its three counterpart volumes it offers the most wide-ranging and authoritative repository of knowledge on infectious diseases, with readily accessed contributions by the world's leading authorities on the subject. The encyclopedia covers the material from all angles, with more than 1000 pages of essays on the genetics, physiology, metabolism, pathogenesis and applied microbiology of all known infectious diseases, and includes access to an e-reference work that will include ongoing updates reflecting the latest advances in the field. An outstanding new resource of immense value to a wide range of medical researchers and practitioners, the encyclopedia features a user-friendly subdivision of diseases according to their affective locus in the human body. The sections cover integumentary, skeletal, respiratory, digestive, urinary, and reproductive transmissible pathogens. This high-profile encyclopedia will be an essential addition to academic libraries worldwide.

Volume Allergic Diseases is a comprehensive, multi-authored reference work, offering a broad appeal to microbiologists, immunologists, and infectious disease specialists. The volume explores all aspects of allergic diseases, body systems and vaccines. Emphasis is placed on genetics, physiology, metabolism, pathogenesis, and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia brings together an outstanding collection of contributions by top scientists in a variety of fields. The entries are listed alphabetically and provide full references. The volume covers the following topics: * Food Allergy and gastrointestinal Allergic Diseases * Insect Allergy * Allergy Diagnosis and Testing * Allergy Treatment: Pharmacotherapy * Asthma and Other Allergic Lower Respiratory Disease * Biology of IgE, Mast Cells and Eosinophils * Specific Allergens Causing Human Disease * Atopic Dermatitis, Urticaria and Dermatologic Allergy * Allergy Treatment: Immunotherapy, Immunomodulator Therapy and Allergen Avoidance

The American Autoimmune Related Diseases Association estimates that one in five Americans, or 50 million people, suffer from autoimmune diseases. An autoimmune disease results when cells and other components of the body's immune system, designed to protect us from invading microbes such as bacteria or viruses, mistakenly attack a person's own organs. These diseases run the gamut from mild to potentially life-threatening, and include chronic fatigue syndrome, hepatitis, multiple sclerosis, rheumatold arthritis, and many others. The Encyclopedia of autoimmune Diseases is the only reference of its kind available to general readers. This comprehensive A-to-Z resource covers the human immune system and what happens when it malfunctions, including details on a wide range of autoimmune diseases, the latest information on treatments, and suggestions on how to cope with them. Several appendixes list common medications used for treatment; organizations offering advocacy, support, and information; related web-sites; and government agencies, More than 300 cross-referenced entries include autoimmunity, bone marrow, cellular immunity (cell-mediated immunity), DNA (deoxyribonucleic acid), fungi, genetic engineering, graft-versus-host disease, leukocytes, mast cells, natural killer (NK) cell, platelets, stem cells, transplant rejection, vaccine, and virus.

This unique volume contains reviews by some of the most prominent immunologists in the world. The authors present vital facts for each of their areas of expertise and provide individual perspectives on how their own contributions were developed and how these contributions influenced general immunological thinking and development. This impressive collection of personal reviews by these internationally renowned immunologists makes The Immunologic Revolution an important and lasting contribution to the entire biomedical community.

Volume Allergic Diseases is a comprehensive, multi-authored reference work, offering a broad appeal to microbiologists, immunologists, and infectious disease specialists. The volume explores all aspects of allergic diseases, body systems and vaccines. Emphasis is placed on genetics, physiology, metabolism, pathogenesis, and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia brings together an outstanding collection of contributions by top scientists in a variety of fields. The entries are listed alphabetically and provide full references. The volume covers the following topics: * Food Allergy and gastrointestinal Allergic Diseases * Insect Allergy * Allergy Diagnosis and Testing * Allergy Treatment: Pharmacotherapy * Asthma and Other Allergic Lower Respiratory Disease * Biology of IgE, Mast Cells and Eosinophils * Specific Allergens Causing Human Disease * Atopic Dermatitis, Urticaria and Dermatologic Allergy * Allergy Treatment: Immunotherapy, Immunomodulator Therapy and Allergen Avoidance