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When I was asked some years ago by the editors of the Handbook of
Experimental Pharmacology to edit a new volume on Antianginal
Drugs, I agreed on the condition that, in accordance with my
scientific background, primary emphasis be given to clinical
pharmacology and therapeutics. It soon turned out that, due to
rapid developments in this field, nothing of the previous volume on
Antianginal Drugs by Charlier (Vol. 31, 1971) could be retained
apart from its basic idea of devoting considerable space to
methodology. Since editors must operate within certain limits, I
had to abstain from dealing with acute myocardial infarction in
detail despite the well-known overlap between unstable angina, the
preinfarction syndrome, and acute myocardial infarction. It was
only possible for acute myocardial infarction and the concept of
reduction of infarct size to be briefly discussed within the
chapter on pathophysiology of acute coronary insufficiency. The
chapter on invasive methods provided an opportunity to touch on new
approaches to early intervention in acute myocardial infarction.
Here, intracoronary streptokinase therapy and PTCA are considered,
again with attention to the overlap between mechanical and
pharmacological interventions.
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