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and how the known vertebrate homologues of these genes are
expressed normally in differentiation and proliferation pathways as
well as abnormal ly in well-defined lymphomagenic and other
oncogenic pathways. What emerged from this meeting are a better
understanding of the evolution of these gene systems themselves and
an elucidation of simpler systems open to more rapid genetic and
molecular genetic analysis to reveal the normal functions of these
genes and their gene products. Thus we sought new answers to
several old questions concerning differenti ation, proliferation,
and neoplastic transformation. We gathered together in an unusual
format - that of the unique Dahlem Workshops - not just to
reiterate data which has recently emerged but to think about how
these findings might lead to new approaches for the understanding
and therapy of the leukemias and lymphomas. We deliberately chose
experts from several different disciplines, ranging from the
clinicians who diag nose, describe, and treat these maladies, to
the molecular geneticists trying to reduce the analysis of the
problem to its simplest variables in the simplest systems
possible."
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