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This detailed collection covers how the biological functions of
histone deacetylases (HDACs) and histone acetyltransferases (HATs)
can be detected in various experimental settings, both in vivo and
in vitro. The book also covers the generation and specificity of
deacetylase inhibitors and how such agents can be used to test
experimental hypotheses. Written for the popular Methods in
Molecular Biology series, chapters include introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, as well as
tips on troubleshooting and avoiding known pitfalls. Comprehensive
and practical, HDAC/HAT Function Assessment and Inhibitor
Development: Methods and Protocols serves as an ideal guide to this
vital area of study.
This fully updated edition provides a series of methods for how
best to assess functions of histone deacetylases and
acetyltransferases. The disease-relevance of dysregulated protein
deacetylation by overexpressed or aberrantly activated histone
deacetylases has spurred an intense search for novel and improved
inhibitors of these enzymes, as reflected in this collection.
Expert contributors explore the generation and evaluation of novel
histone deacetylase inhibitors and new and improved techniques to
assess acetylation-dependent molecular mechanisms in vitro and in
vivo. Written for the highly successful Methods in Molecular
Biology series, chapters include introductions to their respective
topics, lists of the necessary materials and reagents, step-by-step
and readily reproducible laboratory protocols, and tips on
troubleshooting and avoiding known pitfalls. Authoritative and
up-to-date, HDAC/HAT Function Assessment and Inhibitor Development:
Methods and Protocols, Second Edition serves as an ideal guide for
researchers seeking to further elucidate this vital area of study.
This detailed collection covers how the biological functions of
histone deacetylases (HDACs) and histone acetyltransferases (HATs)
can be detected in various experimental settings, both in vivo and
in vitro. The book also covers the generation and specificity of
deacetylase inhibitors and how such agents can be used to test
experimental hypotheses. Written for the popular Methods in
Molecular Biology series, chapters include introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, as well as
tips on troubleshooting and avoiding known pitfalls. Comprehensive
and practical, HDAC/HAT Function Assessment and Inhibitor
Development: Methods and Protocols serves as an ideal guide to this
vital area of study.
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