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An in depth examination of many of the complex issues associated
with planning and optimisation of intensity modulated radiotherapy
treatment. It includes: a presentation of current practice,
techniques and equipment used by medical physicists and others to
deliver radiotherapy treatment; a systems modelling approach in the
formulation of a beam model for optimisation, describing the effect
of X-rays on human body tissues; a deterministic approach to the
inverse problem in radiotherapy, based on weighted iterative least
squares is modified to allow an adaptive scaling of the error to
improve the performance of a general least squares algorithm; a
guided random search methodology, based on genetic algorithms which
is aimed at solving multi-objective optimisation problems is
developed to optimise beam weight/wedge angle as well as coplanar
beam orientation; the overall approach developed is demons trated
practically using both traditional and modern measurement
techniques.
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