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Key Heterocycle Cores for Designing Multitargeting Molecules
provides a helpful overview of current developments in the field.
Following a detailed introduction to the manipulation of
heterocycle cores for the development of dual or multitargeting
molecules, the book goes on to describe specific examples of such
developments, focusing on compounds such as Benzimidazole,
Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the
latest developments in the field, this volume provides a valuable
guide to current approaches in the design and development of
molecules capable of acting on multiple targets. Adapting the
heterocyclic core of a single-target molecule can facilitate its
development into an agent capable of acting on multiple targets.
Such multi-targeting drugs have the potential to become essential
components in the design of novel, holistic treatment plans for
complex diseases, making the design of such active agents an
increasingly important area of research.
Concepts and Experimental Protocols of Modelling and Informatics in
Drug Design discusses each experimental protocol utilized in the
field of bioinformatics, focusing especially on computer modeling
for drug development. It helps the user in understanding the field
of computer-aided molecular modeling (CAMM) by presenting solved
exercises and examples. The book discusses topics such as
fundamentals of molecular modeling, QSAR model generation, protein
databases and how to use them to select and analyze protein
structure, and pharmacophore modeling for drug targets.
Additionally, it discusses data retrieval system, molecular
surfaces, and freeware and online servers. The book is a valuable
source for graduate students and researchers on bioinformatics,
molecular modeling, biotechnology and several members of biomedical
field who need to understand more about computer-aided molecular
modeling.
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