Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research.

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets. Additionally, it discusses data retrieval system, molecular surfaces, and freeware and online servers. The book is a valuable source for graduate students and researchers on bioinformatics, molecular modeling, biotechnology and several members of biomedical field who need to understand more about computer-aided molecular modeling.

Cancer, an abnormal and uncontrolled cell division, has engulfed the lives of unlimited people till date. Etoposide and Teniposide are podophyllotoxin derivatives and have been used clinically for treatment of refractory testicular tumor and cancer. These compounds arrests cell growth by DNA topo II inhibition, which causes double strand breaks in DNA and known as non-interclating topo II inhibitors. They have many side effects, such as myelosuppression, poor water solubility, and the development of resistance so modification is done on it at various sites. Podophyllotoxin contains a five-ring system. Modification of the A-ring gave compounds having significant activity but less than that of Etoposide, whereas modification of the B-ring resulted in the loss of activity. E-ring is essential for its anticancer activity and D-ring in lactone form is preferred for better activity. The introduction of double bond in C-ring lowers the activity but modifications at the C-4 in C-ring with bulkier groups enhance anticancer activity. NK-611, GL-331 and Etoposide phosphate are water soluble derivatives of Etoposide with potent anticancer activity and are currently in clinical trials.