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This is the first book to provide a broad framework for obtaining
an in depth understanding of the state-of-the-art knowledge on
abnormalities of non-coding RNAs found to be associated with
colorectal cancer pathogenesis. Readers will discover possible
mechanisms underlying the substantial roles played by non-coding
RNAs in molecular hallmarks of colorectal cancer. This work further
provides the comprehensive overview and novel insights into using
of non-coding RNAs as colorectal cancer biomarkers enabling early
detection of the disease, prognostic stratification of the patients
and prediction of therapeutic response. The reader is introduced to
the overview of modern non-coding RNAs-based therapeutic
strategies, and summary of their preclinical testing performed in
colorectal cancer. The work is written for researchers who want to
explore current state of the knowledge in this interesting field of
molecular oncology.
This is the first book to provide a broad framework for obtaining
an in depth understanding of the state-of-the-art knowledge on
abnormalities of non-coding RNAs found to be associated with
colorectal cancer pathogenesis. Readers will discover possible
mechanisms underlying the substantial roles played by non-coding
RNAs in molecular hallmarks of colorectal cancer. This work further
provides the comprehensive overview and novel insights into using
of non-coding RNAs as colorectal cancer biomarkers enabling early
detection of the disease, prognostic stratification of the patients
and prediction of therapeutic response. The reader is introduced to
the overview of modern non-coding RNAs-based therapeutic
strategies, and summary of their preclinical testing performed in
colorectal cancer. The work is written for researchers who want to
explore current state of the knowledge in this interesting field of
molecular oncology.
Digestive tumours are the most frequent malignant tumours in the
world and the leading cause of a cancer-related death. They are
tough to treat once they have formed and many are not found until
they have already spread to other parts of the body. Therefore, new
biomarkers enabling early diagnosis of asymptomatic disease,
accurate differentiation among particular clinical stages and
individualization of therapy are sorely needed. With improved
methods to explore the transcriptome, different types of non-coding
RNAs have been identified. It was proved that these molecules are
highly deregulated in cancer tissue and involved in important
molecular and biological processes such as differentiation,
proliferation, apoptosis, migration or cell cycle. Moreover,
detailed analyses revealed that they could serve as new molecular
markers useful for cancer classification, prognostic
stratification, and drug response prediction. Non-coding RNAs in
Gastrointestinal Cancer offers a comprehensive collection of
current information about the role of non-coding RNAs in
gastrointestinal cancer pathogenesis and illustrates, how this
knowledge may be useful in medical practice.
MiRNA is an extremely fast growing field, and miRNA knowledge is
now believed to be a pivotal element of cancer biology. It is
already evident that the discovery of miRNA has created a paradigm
shift in post-genomics biology, not only for scientists accustomed
to traditional central dogma of molecular biology but also for
researchers studying human diseases and accustomed to traditional
genetics approach of studying one gene at the time. This book
provides an introduction to the basic principles of miRNA biology,
overview of miRNA significance in the hallmarks of cancer,
experimental techniques used in miRNA research, and in special part
- miRNAs importance in wide range of solid cancers with a special
focus on its potential usage in molecular pathology, predictive
oncology or as a novel therapeutic targets.
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