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The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system - poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.
Scientific evidence clearly shows that chlorine and bromine compounds, such as CFCs, released into the atmosphere are responsible for continuous and progressive global ozone losses superimposed by dramatic seasonal ozone depletions first observed over Antarctica, now occurring over Arctic regions as well. Today substitutes are produced and emitted, some of which are highly reactive substances. This handbook volume deals with these reactive halogen compounds and their interactions. It provides a review on the present knowledge of their properties, applications, sources, sinks as well as international regulations.
The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system - poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.
Scientific evidence clearly shows that chlorine and bromine compounds, such as CFCs, released into the atmosphere are responsible for continuous and progressive global ozone losses superimposed by dramatic seasonal ozone depletions first observed over Antarctica, now occurring over Arctic regions as well. Today substitutes are produced and emitted, some of which are highly reactive substances. This handbook volume deals with these reactive halogen compounds and their interactions. It provides a review on the present knowledge of their properties, applications, sources, sinks as well as international regulations.
This book maps out the frontiers of optical technology in two major subdisciplines: optical materials and optical devices. The optical materials and material architectures covered include nanostructured silicon, chiral sculptured thin films, magnetic photonic crystals, and switchable materials for efficient lighting and decorative optics. The optical devices addressed include silicon waveguides for integrated circuitry, high-speed electro-optic modulators, laser diodes coupled with fibre-tip lenses, and optical sensors. Reading the ten chapters, either altogether or piecemeal, the reader will receive a virtually up-to-date review of the state of the art.
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