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This book takes a systematic approach to nanotoxicology and the
developing risk factors associated with nanosized particles during
manufacture and use of nanotechnology. Beginning with a detailed
introduction to engineered nanostructures, the first part of the
book presents concepts and definitions of nanomaterials from
quantum dots to graphene to fullerenes, with detailed discussion of
functionalization, stability, and medical and biological
applications. The second part critically examines methodologies
used to assess cytotoxicity and genotoxicity. Coverage includes
interactions with blood (erythrocytes), combinatorial and
microarray techniques, cellular mechanisms, and ecotoxicology
assessments. Part three describes cases studies both in vitro and
in vivo for specific nanomaterials including solid lipid
nanoparticles and nanostructured lipid carriers and metallic
nanoparticles and metallic oxides. New information is also
presented on toxicological aspects of poloxamers and polymeric
nanoparticles as drug carriers as well as size effects on
cytotoxicity and genotoxicity. Didactic aspects are emphasized in
all chapters, making the book suitable for a broad audience ranging
from advanced undergraduate and graduate students to researchers in
academia and industry. In all, Nanotoxicology: Materials,
Methodologies, and Assessments will provide comprehensive insight
into biological and environmental interactions with nanostructures.
Provides an introduction to nanostructures actually in use
Describes cyto- and genotoxicity methodologies, and assesses their
performance in comparison to common toxicity assays Discusses the
relation of cytotoxicity and genotoxicity to ecotoxicity Presents a
range of applications, from biogenic silver nanoparticles to
poloxamers as drug-delivery systems, reflecting the expanding
applications of nanotechnology
This book takes a systematic approach to nanotoxicology and the
developing risk factors associated with nanosized particles during
manufacture and use of nanotechnology. Beginning with a detailed
introduction to engineered nanostructures, the first part of the
book presents concepts and definitions of nanomaterials from
quantum dots to graphene to fullerenes, with detailed discussion of
functionalization, stability, and medical and biological
applications. The second part critically examines methodologies
used to assess cytotoxicity and genotoxicity. Coverage includes
interactions with blood (erythrocytes), combinatorial and
microarray techniques, cellular mechanisms, and ecotoxicology
assessments. Part three describes cases studies both in vitro and
in vivo for specific nanomaterials including solid lipid
nanoparticles and nanostructured lipid carriers and metallic
nanoparticles and metallic oxides. New information is also
presented on toxicological aspects of poloxamers and polymeric
nanoparticles as drug carriers as well as size effects on
cytotoxicity and genotoxicity. Didactic aspects are emphasized in
all chapters, making the book suitable for a broad audience ranging
from advanced undergraduate and graduate students to researchers in
academia and industry. In all, Nanotoxicology: Materials,
Methodologies, and Assessments will provide comprehensive insight
into biological and environmental interactions with nanostructures.
Provides an introduction to nanostructures actually in use
Describes cyto- and genotoxicity methodologies, and assesses their
performance in comparison to common toxicity assays Discusses the
relation of cytotoxicity and genotoxicity to ecotoxicity Presents a
range of applications, from biogenic silver nanoparticles to
poloxamers as drug-delivery systems, reflecting the expanding
applications of nanotechnology
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