This book explores the nature of regions and how they function, particularly at the local and micro-level. Whilst recent years have seen a resurgence in debates around the roles which regions can play in development, the focus has tended to be on 'macro' regional institutions such as the EU, ASEAN, ECOWAS or MERCOSUR. In contrast, this book offers a nuanced analysis of the important field of sub-regionalism and sub-national cross-border cooperation. Region-Making and Cross-Border Cooperation takes a fresh look at both theoretical and empirical approaches to 'region-making' through cooperation activities at the micro-level across national borders in Europe, Southeast Asia, Latin America, Africa and the Middle East. The book aims to explore the role that institutional dynamics play at the micro-level in shaping local and global ties, investigate what the formal and informal integration factors are that bolster regionalism and regionalization processes, and to clarify to what extent, and under what conditions, cooperation at the micro-level can be instrumental to solving common problems. Scholars and students within politics, sociology, geography, and economics would find this book an important guide to regionalism at a micro-local level perspective.