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Intravenous infusion is a necessary mode of delivery for many
pharmaceuticals currently on the market or undergoing clinical
trials. The technique of prolonged intravenous delivery in
conscious, free-moving animal models has broadened the opportunity
to study and evaluate the safety and efficacy of these therapeutic
products. With contributions from an international selection of
authors who are leaders in commercial infusion technology,
Non-Clinical Vascular Infusion Technology, Volume II: The
Techniques provides a current account of the techniques involved in
all the major laboratory animal species for conducting successful
vascular infusion studies with xenobiotics. Following in the
footsteps of the highly praised Handbook of Pre-Clinical Continuous
Intravenous Infusion, this new volume covers both up-to-date
procedures and equipment. It is organized by species, including all
those commonly used in pre-clinical studies: rat, mouse, dog,
minipig, large primate, and marmoset. There are also chapters on
juvenile studies and reproductive toxicity studies. Each section
addresses the selection of the best model, surgical and
non-surgical best practices, practical techniques, equipment
selection, and commonly encountered background pathologies. Using a
fresh approach, the authors identify best practices to be shared
across the industry, and provide guidance on choices for the most
acceptable methodologies from an animal welfare perspective. This
volume, along with Volume I: The Science, provides a foundation of
knowledge on infusion technology and its importance for safe
clinical use of substances via this route of delivery. Features:
Emphasizes best practices in accordance with the 3Rs-reduction,
refinement, and replacement of animal usage in laboratories
Presents step-by-step procedures and practical tips covering a wide
range of common animal models, augmented by the liberal use of
illustrations Covers modern practices and procedures in accordance
with up-to-date equipment development
Intravenous infusion is a necessary mode of delivery for many
pharmaceuticals currently on the market or undergoing clinical
trials. The technique of prolonged intravenous delivery in
conscious, free-moving animal models has broadened the opportunity
to study and evaluate the safety and efficacy of these therapeutic
products. For the first time, the collective sciences involved in
the understanding of this mode of drug delivery are brought
together in one publication. Non-Clinical Vascular Infusion
Technology, Volume I: The Science covers the scientific principles
behind the delivery systems, from both physical and physiological
standpoints. The book addresses body fluid dynamics, describes the
scientific processes necessary to understand the various aspects of
the physico-chemical issues relating to vascular infusion delivery,
and discusses vascular infusion dynamics. It also considers all the
essential elements of the preparation of a formulation intended for
vascular delivery as well as assessment of compatibility of the
formulation with the dosing apparatus. This volume, along with
Volume II: The Techniques, provides a foundation of knowledge on
infusion technology and its importance for safe clinical use of
substances via this route of delivery. Features Identifies and
shares best practices for non-clinical vascular infusion Presents
modern practices and procedures in line with up-to-date equipment
development Offers recommendations for in-life assessments in order
to monitor the success or problems with the vascular infusion
delivery Makes comparisons with human data in many areas
Intravenous infusion is a necessary mode of delivery for many
pharmaceuticals currently on the market or undergoing clinical
trials. The technique of prolonged intravenous delivery in
conscious, free-moving animal models has broadened the opportunity
to study and evaluate the safety and efficacy of these therapeutic
products. For the first time, the collective sciences involved in
the understanding of this mode of drug delivery are brought
together in one publication.
Non-Clinical Vascular Infusion Technology, Volume I: The Science
covers the scientific principles behind the delivery systems, from
both physical and physiological standpoints. The book addresses
body fluid dynamics, describes the scientific processes necessary
to understand the various aspects of the physico-chemical issues
relating to vascular infusion delivery, and discusses vascular
infusion dynamics. It also considers all the essential elements of
the preparation of a formulation intended for vascular delivery as
well as assessment of compatibility of the formulation with the
dosing apparatus. This volume, along with "Volume II: The
Techniques," provides a foundation of knowledge on infusion
technology and its importance for safe clinical use of substances
via this route of delivery.
Features
- Identifies and shares best practices for non-clinical vascular
infusion
- Presents modern practices and procedures in line with
up-to-date equipment development
- Offers recommendations for in-life assessments in order to
monitor the success or problems with the vascular infusion
delivery
- Makes comparisons with human data in many areas
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