This book constitutes the refereed proceedings of the 28th International Symposium on Model Checking Software, SPIN 2022, held virtually in May 2022.The 8 full papers were carefully reviewed and selected from 11 submissions. Topics covered include formal verification techniques for automated analysis of software; formal analysis for modeling languages, such as UML/state charts; formal specification languages, temporal logic, design-by-contract; model checking, automated theorem proving, including SAT and SMT; verifying compilers; abstraction and symbolic execution techniques; and much more.