Parasitic diseases are the most widespread of all the major diseases, currently 9 affecting about 3 x 10 people and innumerable domestic animals. There is no doubt that among these parasitic diseases, the helminthic infections of the gastrointestinal tract are about the most important because of their global distribution, their high prevalence, their effects on the nutritional status of men and animals, their effects on the physical and mental development of children, and their economic effects on the production of animals. Anthelmintics are important elements in the control of these gastrointestinal helminthic infections. In this volume the editors and authors have tried to find a way through the immense amount of information on anthelmintic drugs that is scattered throughout the literature. Different authors have critically examined this information from different angles. However, the aim of all has been to provide the information needed by veterinarians, physicians, and public health workers to select the most suitable drug for a given situation.

In an alternate version of London in 1895, a few talented people can travel instantly between locations through Thresholds - tears in the fabric of reality. Lord Henry Lewis is a Warden, working to close dangerous Thresholds to prevent the sickness that flows from the darkness outside reality. William Marsh loses his family to the sickness when several undirected Thresholds are opened in his home. Marsh has the born talent to open Thresholds, and Lord Lewis's superiors order him to train the young man. Their relationship is strained, but they slowly come to rely on each other. The number of rogue Thresholds is increasing and times are dangerous. Lewis and Marsh discover that a cult, disillusioned by the scientific advances of the age, is opening the rogue Thresholds to destroy mankind. As London falls into darkness, they must race against time to stop the end of the world.